ArticleRespiratory research2003
Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways.
Article in Respiratory research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation.Advances in experimental medicine and biology · 2022Article
- Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma.Pharmacological reports : PR · 2020Article
- Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model.Pharmacology research & perspectives · 2019Article
- Modelling the asthma phenotype: impact of cigarette smoke exposure.Respiratory research · 2018Article
- Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma.Journal of Zhejiang University. Science. B · 2015Article
- Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation.American journal of respiratory and critical care medicine · 2015Article
- Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD.PloS one · 2014Article
- Dysregulation of alveolar macrophages unleashes dendritic cell-mediated mechanisms of allergic airway inflammation.Mucosal immunology · 2014Article
- From bedside to bench to clinic trials: identifying new treatments for severe asthma.Disease models & mechanisms · 2013Review
- Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway.American journal of respiratory and critical care medicine · 2010Article
- Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.American journal of respiratory and critical care medicine · 2009Article
- GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma.Respiratory research · 2009Article
- Non-asthmatic patients show increased exhaled nitric oxide concentrations.Clinics (Sao Paulo, Brazil) · 2009Article
- The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice.Respiratory research · 2008Article
- Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma.Respiratory research · 2007Article
- Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease.PPAR research · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe link between eosinophils and the development of airway hyperresponsiveness (AHR) in asthma is still controversial. This question was assessed in a murine model of asthma in which we performed a dose ranging study to establish whether the dose of steroid needed to inhibit the eosinophil infiltration correlated with that needed to block AHR.
methodsThe sensitised BALB/c mice were dosed with vehicle or dexamethasone (0.01-3 mg/kg) 2 hours before and 6 hours after each challenge (once daily for 6 days) and 2 hours before AHR determination by whole-body plethysmography. At 30 minutes after the AHR to aerosolised methacholine the mice were lavaged and differential white cell counts were determined. Challenging with antigen caused a significant increase in eosinophils in the bronchoalveolar lavage (BAL) fluid and lung tissue, and increased AHR.
resultsDexamethasone reduced BAL and lung tissue eosinophilia (ED50 values of 0.06 and 0.08 mg/kg, respectively), whereas a higher dose was needed to block AHR (ED50 of 0.32 mg/kg at 3 mg/ml methacholine. Dissociation was observed between the dose of steroid needed to affect AHR in comparison with eosinophilia and suggests that AHR is not a direct consequence of eosinophilia.
conclusionThis novel pharmacological approach has revealed a clear dissociation between eosinophilia and AHR by using steroids that are the mainstay of asthma therapy. These data suggest that eosinophilia is not associated with AHR and questions the rationale that many pharmaceutical companies are adopting in developing low-molecular-mass compounds that target eosinophil activation/recruitment for the treatment of asthma.
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