Evidence map›Paper›PMID 12655404›Full record

ArticleMolecular genetics and genomics : MGG2003

Patterns of Hermes transposition in Drosophila melanogaster.

N Guimond, D K Bideshi, A C Pinkerton, P W Atkinson, D A O'Brochta

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

N GuimondCenter for Biosystems Research, Plant Sciences Building, Room 5115, University of Maryland Biotechnology Institute, College Park 20742-4450, USA.
D K Bideshi
A C Pinkerton
P W Atkinson
D A O'Brochta
University of California, Riverside · USBiotechnology Institute · USUniversity of California System · USUniversity of Maryland, College Park · US

Funding

HERMES ELEMENT TRANSPOSITION IN MOSQUITOESR01AI045741 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ATKINSON, PETER WILLIAM · 1999 to 2008
$2.9M
HOBO-LIKE TRANSPOSABLE ELEMENTS IN INSECTSR01GM048102 · NIGMS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI O'BROCHTA, DAVID A · 1992 to 2008
$2.8M
NIAID NIH HHS AI45741NIGMS NIH HHS GM48102
6 · The paper itself

Abstract

Transposable elements are being developed as tools for genomics and for the manipulation of insect genotypes for the purposes of biological control. An understanding of their transposition behavior will facilitate the use of these elements. The behavior of an autonomous Hermes transposable element from Musca domestica in the soma and germ-line of Drosophila melanogaster was investigated using the method of transposon display. In the germ-line, Hermes transposed at a rate of approximately 0.03 jumps per element per generation. Within the soma Hermes exhibited markedly non-random patterns of integration. Certain regions of the genome were distinctly preferred over others as integration targets, while other regions were underrepresented among the integration sites used. One particular site accounted for 4.4% of the transpositions recovered in this experiment, all of which were located within a 2.5-kb region of the actin5C promoter. This region was also present within the Hermes element itself, suggesting that this clustering is an example of transposable element "homing". Clusters of integration sites were also observed near the original donor sites; these represent examples of local hopping. The information content (sequence specificity) of the 8-bp target site was low, and the consensus target site resembles that determined from plasmid-based integration assays.

Indexed as

AnimalsAnimals, Genetically ModifiedBase SequenceChromosomesDNA Transposable ElementsDrosophila melanogasterFemaleGenes, InsectGenomeMaleDNA Transposable Elements

Identifiers

PMID12655404
OpenAlexW30412625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.