ArticleIntensive care medicine2003
Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma.
Article in Intensive care medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 92 citations in OpenAlex.
- Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial.BMC anesthesiology · 2017Trial
- Intensive versus conventional insulin therapy in critically ill neurologic patients.Neurocritical care · 2010Trial
- Inpatient hyperglycemia following aneurysmal subarachnoid hemorrhage: relation to cerebral metabolism and outcome.Neurocritical care · 2009Trial
- Glucose and Lactate Concentrations in Plasma, Cerebrospinal Fluid, and Brain Parenchyma Following Aneurysmal Subarachnoid Hemorrhage: A Cross-compartmental Correlation Study.Neurocritical care · 2026Article
- Relationship Between Systemic and Cerebral Microdialysate Glucose in Patients With Severe Acute Brain Injury-A Retrospective Study.Acta anaesthesiologica Scandinavica · 2025Observational
- Preliminary Observations of the Loke Microdialysis in an Experimental Pig Model: Are We Ready for Continuous Monitoring of Brain Energy Metabolism?Neurocritical care · 2025Article
- Cerebral Glucose Metabolism following TBI: Changes in Plasma Glucose, Glucose Transport and Alternative Pathways of Glycolysis-A Translational Narrative Review.International journal of molecular sciences · 2024Review
- High-physiological and supra-physiological 1,2-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Cerebral microdialysis and glucopenia in traumatic brain injury: A review.Frontiers in neurology · 2023Review
- Article
- Fine Tuning of Traumatic Brain Injury Management in Neurointensive Care-Indicative Observations and Future Perspectives.Frontiers in neurology · 2021Review
- Determination of calorie and protein intake among acute and sub-acute traumatic brain injury patients.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2020Observational
- Enteral nutrition increases interstitial brain glucose levels in poor-grade subarachnoid hemorrhage patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Observational
- Glycemia Is Related to Impaired Cerebrovascular Autoregulation after Severe Pediatric Traumatic Brain Injury: A Retrospective Observational Study.Frontiers in pediatrics · 2017Article
- Glucose administration after traumatic brain injury exerts some benefits and no adverse effects on behavioral and histological outcomes.Brain research · 2015Article
- Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings.Metabolic brain disease · 2015Review
- Increased blood glucose is related to disturbed cerebrovascular pressure reactivity after traumatic brain injury.Neurocritical care · 2015Article
- Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?Current neuropharmacology · 2014Article
- Effects of Glycemic Level on Outcome of Patients with Traumatic Brain Injury: A Retrospective Cohort Study.Bulletin of emergency and trauma · 2014Article
- Glucose and the injured brain-monitored in the neurointensive care unit.Frontiers in neurology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study whether transient hyperglycemia adversely affects cerebral energy metabolism in patients with severe traumatic brain lesions. DESIGN AND
settingProspective, nonrandomized study in the neurosurgical intensive care unit of a university hospital. PATIENTS: 108 patients treated for severe traumatic brain lesions.
interventionsAll patients were treated according to neurosurgical intensive care routine including monitoring of intracranial pressure. One microdialysis catheter was inserted via a burr hole frontally to that used for the intraventricular catheter ("better" position). In patients with focal lesions one or more catheters were inserted into cerebral cortex surrounding an evacuated focal contusion or underlying an evacuated hematoma ("worse" position). Perfusion rate was 0.3 micro l/min and samples were taken every 30 or 60 min. The levels of glucose, pyruvate, lactate, glutamate, and glycerol were analyzed and displayed bedside. MEASUREMENTS AND
resultsThere were 18 episodes of moderate (12-15 mmol/l) and 6 episodes of pronounced (>15 mmol/l) hyperglycemia. Moderate hyperglycemia did not change intracerebral levels of lactate, pyruvate, glutamate, glycerol, or lactate/pyruvate ratio. Lactate concentrations increased during pronounced hyperglycemia. Pronounced cerebral lactic acidosis and a moderate increase in interstitial glycerol concentration indicating cell membrane degradation was observed in a single patient with pronounced, long-lasting hyperglycemia.
conclusionsCerebral energy metabolism was affected by transient hyperglycemia only at blood glucose concentration above 15 mmol/l as shown by a moderate increase in interstitial lactate level.
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Registered trials
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