ArticleProceedings of the National Academy of Sciences of the United States of America2003
Analysis of the eye developmental pathway in Drosophila using DNA microarrays.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 83 citations in OpenAlex.
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
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- Functional Genomics of the Retina to Elucidate its Construction and Deconstruction.International journal of molecular sciences · 2019Review
- Predicting gene regulatory interactions based on spatial gene expression data and deep learning.PLoS computational biology · 2019Article
- Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.Nucleic acids research · 2018Article
- Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium.Development (Cambridge, England) · 2018Article
- Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.PLoS genetics · 2018Article
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- Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster.Scientific reports · 2015Article
- Predictable transcriptome evolution in the convergent and complex bioluminescent organs of squid.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Receptor tyrosine kinases in Drosophila development.Cold Spring Harbor perspectives in biology · 2013Review
- Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.PloS one · 2013Article
- Interpreting the regulatory genome: the genomics of transcription factor function in Drosophila melanogaster.Briefings in functional genomics · 2012Article
- Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development.Development (Cambridge, England) · 2012Article
- Regulation of behaviorally associated gene networks in worker honey bee ovaries.The Journal of experimental biology · 2012Article
- Article
- Identification and characterization of gene expression involved in the coloration of cichlid fish using microarray and qRT-PCR approaches.Journal of molecular evolution · 2011Article
- Chance and necessity in eye evolution.Genome biology and evolution · 2011Article
- The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs.Genetics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pax-6 genes encode evolutionarily conserved transcription factors capable of activating the gene-expression program required to build an eye. When ectopically expressed in Drosophila imaginal discs, Pax-6 genes induce the eye formation on the corresponding appendages of the adult fly. We used two different Drosophila full-genome DNA microarrays to compare gene expression in wild-type leg discs versus leg discs where eyeless, one of the two Drosophila Pax-6 genes, was ectopically expressed. We validated these data by analyzing the endogenous expression of selected genes in eye discs and identified 371 genes that are expressed in the eye imaginal discs and up-regulated when an eye morphogenetic field is ectopically induced in the leg discs. These genes mainly encode transcription factors involved in photoreceptor specification, signal transducers, cell adhesion molecules, and proteins involved in cell division. As expected, genes already known to act downstream of eyeless during eye development were identified, together with a group of genes that were not yet associated with eye formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.