ArticleNucleic acids research2003
Scp160p associates with specific mRNAs in yeast.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- The dual functions of the GTPase BipA in ribosome assembly and surface structure biogenesis in Salmonella enterica serovar Typhimurium.PLoS pathogens · 2025Article
- Translational regulation in response to stress in Saccharomyces cerevisiae.Yeast (Chichester, England) · 2019Review
- RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression forG3 (Bethesda, Md.) · 2017Article
- Tma108, a putative M1 aminopeptidase, is a specific nascent chain-associated protein in Saccharomyces cerevisiae.Nucleic acids research · 2016Article
- Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.Scientific reports · 2015Article
- Scp160p is required for translational efficiency of codon-optimized mRNAs in yeast.Nucleic acids research · 2014Article
- Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae.Molecular biology of the cell · 2013Article
- RACK1 Function in Cell Motility and Protein Synthesis.Genes & cancer · 2013Review
- Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast.Cell reports · 2012Article
- Specialized ribosomes: a new frontier in gene regulation and organismal biology.Nature reviews. Molecular cell biology · 2012Review
- The SESA network links duplication of the yeast centrosome with the protein translation machinery.Genes & development · 2009Article
- Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system.PLoS biology · 2008Article
- Post-transcriptional gene regulation: from genome-wide studies to principles.Cellular and molecular life sciences : CMLS · 2008Review
- Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160.Nucleic acids research · 2007Article
- Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160.Nucleic acids research · 2007Article
- Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes.The Biochemical journal · 2004Article
- Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.Eukaryotic cell · 2004Article
- Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast.PLoS biology · 2004Article
- Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast.Nucleic acids research · 2004Article
- RNA asymmetric distribution and daughter/mother differentiation in yeast.Current opinion in microbiology · 2003Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scp160p is a multiple KH-domain RNA-binding protein in yeast that has been demonstrated previously to associate with both soluble and membrane-bound polyribosomes as an mRNP component. One key question that has remained unanswered, however, is whether the mRNAs in these mRNP complexes are random or specific. We have addressed this question using microarray analyses of RNAs released from affinity isolated Scp160p-containing complexes, compared with total RNA controls from the same lysates. Our results, confirmed by quantitative RT-PCR analysis, clearly demonstrate that Scp160p associates with specific rather than with random messages, and that among the enriched targets are DHH1, YOR338W, BIK1, YOL155C and NAM8. Furthermore, loss of Scp160p resulted in a significant change in both the abundance and distribution between soluble and membrane-associated fractions for at least one of these messages (YOR338W), and in a subtle yet significant shift from soluble polyribosomes to soluble mRNPs for at least two of these target messages (DHH1 and YOR338W). Together, these data not only identify specific mRNA targets associated with Scp160p in vivo, they demonstrate that the association of Scp160p with these messages is biologically relevant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.