ArticleInfection and immunity2003
Major histocompatibility complex heterozygote superiority during coinfection.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 219 citations in OpenAlex.
- Article
- Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.BMC genomics · 2024Article
- Relationship between genome-wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate.Ecology and evolution · 2022Article
- Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads,Conservation genetics (Print) · 2022Article
- What evolutionary processes maintain MHC IIꞵ diversity within and among populations of stickleback?Molecular ecology · 2021Article
- Interplay Between Class II HLA Genotypes and the Microbiome and Immune Phenotypes in Individuals With PTEN Hamartoma Tumor Syndrome.JCO precision oncology · 2021Article
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- Article
- Marriage does not relate to major histocompatibility complex: a genetic analysis based on 3691 couples.Proceedings. Biological sciences · 2020Article
- MHC-associatedInternational journal for parasitology. Parasites and wildlife · 2020Article
- No evidence for a relationship between MHC heterozygosity and life history strategy in a sample of North American undergraduates.Scientific reports · 2020Article
- The Genetic Mechanisms Driving Diversification of theFrontiers in immunology · 2020Review
- Seeing-good-gene-based mate choice: From genes to behavioural preferences.The Journal of animal ecology · 2019Article
- "Balancing" balancing selection? Assortative mating at the major histocompatibility complex despite molecular signatures of balancing selection.Ecology and evolution · 2019Article
- Article
- Major histocompatibility complex-linked social signalling affects female fertility.Proceedings. Biological sciences · 2017Article
- Population Genetics and Natural Selection in Rheumatic Disease.Rheumatic diseases clinics of North America · 2017Review
- Article
- Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos.BMC evolutionary biology · 2017Article
- Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins.Ecology and evolution · 2016Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Genes of the major histocompatibility complex (MHC) play a critical role in immune recognition, and many alleles confer susceptibility to infectious and autoimmune diseases. How these deleterious alleles persist in populations is controversial. One hypothesis postulates that MHC heterozygote superiority emerges over multiple infections because MHC-mediated resistance is generally dominant and many allele-specific susceptibilities to pathogens will be masked by the resistant allele in heterozygotes. We tested this hypothesis by using experimental coinfections with Salmonella enterica (serovar Typhimurium C5TS) and Theiler's murine encephalomyelitis virus (TMEV) in MHC-congenic mouse strains where one haplotype was resistant to Salmonella and the other was resistant to TMEV. MHC heterozygotes were superior to both homozygotes in 7 out of 8 comparisons (P = 0.0024), and the mean standardized pathogen load of heterozygotes was reduced by 41% over that of homozygotes (P = 0.01). In contrast, no heterozygote superiority was observed when the MHC haplotype combinations had similar susceptibility profiles to the two pathogens. This is the first experimental evidence for MHC heterozygote superiority against multiple pathogens, a mechanism that would contribute to the evolution of MHC diversity and explain the persistence of alleles conferring susceptibility to disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.