ArticleInfection and immunity2003
Recognition of mycobacterial epitopes by T cells across mammalian species and use of a program that predicts human HLA-DR binding peptides to predict bovine epitopes.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026Article
- Pepscan and bioinformatic strategies for identification of potential B-cell epitopes for a peptide-based vaccine for tick control.Molecular and biochemical parasitology · 2025Article
- Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection.Nature communications · 2024Article
- Selection of vaccine-candidate peptides fromFrontiers in immunology · 2024Article
- A defined antigen skin test for the diagnosis of bovine tuberculosis.Science advances · 2019Article
- Mining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations.Parasites & vectors · 2017Article
- Integrated computational prediction and experimental validation identifies promiscuous T cell epitopes in the proteome ofMicrobial genomics · 2016Article
- Comparative Genomics and Proteomic Analysis of Four Non-tuberculous Mycobacterium Species and Mycobacterium tuberculosis Complex: Occurrence of Shared Immunogenic Proteins.Frontiers in microbiology · 2016Article
- Antigens for CD4 and CD8 T cells in tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- Molecular characterization and identification of Th1 epitopes of a Schistosoma japonicum protein similar to prosaposin.Parasitology research · 2014Article
- Function and Potentials of M. tuberculosis Epitopes.Frontiers in immunology · 2014Review
- In silico analysis and experimental validation of Mycobacterium tuberculosis -specific proteins and peptides of Mycobacterium tuberculosis for immunological diagnosis and vaccine development.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Review
- Bioinformatic and empirical analysis of novel hypoxia-inducible targets of the human antituberculosis T cell response.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?Expert review of vaccines · 2012Article
- pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes.Immunome research · 2010Article
- Screening of predicted secreted antigens from Mycobacterium bovis reveals the immunodominance of the ESAT-6 protein family.Infection and immunity · 2010Article
- Screening of highly expressed mycobacterial genes identifies Rv3615c as a useful differential diagnostic antigen for the Mycobacterium tuberculosis complex.Infection and immunity · 2008Article
- Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses.BMC medical genomics · 2008Article
- Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level.Clinical and vaccine immunology : CVI · 2007Article
- A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes.Journal of biosciences · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioinformatics tools have the potential to accelerate research into the design of vaccines and diagnostic tests by exploiting genome sequences. The aim of this study was to assess whether in silico analysis could be combined with in vitro screening methods to rapidly identify peptides that are immunogenic during Mycobacterium bovis infection of cattle. In the first instance the M. bovis-derived protein ESAT-6 was used as a model antigen to describe peptides containing T-cell epitopes that were frequently recognized across mammalian species, including natural hosts for tuberculosis (humans and cattle) and small-animal models of tuberculosis (mice and guinea pigs). Having demonstrated that some peptides could be recognized by T cells from a number of M. bovis-infected hosts, we tested whether a virtual-matrix-based human prediction program (ProPred) could identify peptides that were recognized by T cells from M. bovis-infected cattle. In this study, 73% of the experimentally defined peptides from 10 M. bovis antigens that were recognized by bovine T cells contained motifs predicted by ProPred. Finally, in validating this observation, we showed that three of five peptides from the mycobacterial antigen Rv3019c that were predicted to contain HLA-DR-restricted epitopes were recognized by T cells from M. bovis-infected cattle. The results obtained in this study support the approach of using bioinformatics to increase the efficiency of epitope screening and selection.
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