ArticleInfection and immunity2003
Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Review of current diagnostic methods and advances inWorld journal of gastroenterology · 2019Review
- Chitosan as an adjuvant for a Helicobacter pylori therapeutic vaccine.Molecular medicine reports · 2015Article
- In silico experiment with an-antigen-toll like receptor-5 agonist fusion construct for immunogenic application to Helicobacter pylori.Indian journal of human genetics · 2013Article
- Vaccinating against Helicobacter pylori infection.Nature reviews. Gastroenterology & hepatology · 2011Review
- Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.Gastroenterology · 2011Article
- Helicobacter pylori: bacterial factors and the role of cytokines in the immune response.Current microbiology · 2010Article
- Recent advances that favor development of a vaccine for Helicobacter pylori infection.Pediatric health · 2008Article
- Th immune response induced by H pylori vaccine with chitosan as adjuvant and its relation to immune protection.World journal of gastroenterology · 2007Article
- Influence of age and duration of infection on bacterial load and immune responses to Helicobacter pylori infection in a murine model.Clinical and experimental immunology · 2005Article
- Mucosally delivered Salmonella live vector vaccines elicit potent immune responses against a foreign antigen in neonatal mice born to naive and immune mothers.Infection and immunity · 2004Article
- Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.Infection and immunity · 2004Article
- Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Helicobacter pylori infection of the gastric mucosa is a significant cause of morbidity and mortality because of its etiologic role in symptomatic gastritis, peptic ulcer disease, and gastric adenocarcinoma. Infection occurs in young children; therefore, a prophylactic vaccine would have to be administered within the first year of life, a period thought to be immunologically privileged. We investigated vaccine formulations administered by different routes to confer protective anti-H. pylori immunity in neonatal mice. Neonatal mice immunized with a single dose of vaccine in complete Freund's adjuvant (CFA) generated antigen-specific gamma interferon-, interleukin-2 (IL-2)-, IL-4-, and IL-5-secreting T cells in numbers similar to those in immunized adult mice, while vaccine administered to neonates in incomplete Freund's adjuvant (IFA) induced such cells in reduced numbers compared to those in adult mice. Both IFA and CFA, however, provided partial protection from a challenge with infectious H. pylori when the vaccine was administered subcutaneously. Neonatal immunized mice also had reduced bacterial loads when immunized intraperitoneally with CFA. In all cases, protection was equivalent to that achieved when adult counterparts were immunized. These studies suggest that an efficacious vaccine might be successfully administered to very young children to prevent perinatal infection of H. pylori.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.