ArticleAntimicrobial agents and chemotherapy2003
Rifampin followed by ceftriaxone for experimental meningitis decreases lipoteichoic acid concentrations in cerebrospinal fluid and reduces neuronal damage in comparison to ceftriaxone alone.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial.The Journal of antimicrobial chemotherapy · 2019Trial
- Bilateral functional hippocampectomy following recurrent bacterial meningitis: a case report.Journal of medical case reports · 2026Article
- Understanding the mechanisms ofTissue barriers · 2025Review
- Crocin has pharmacological effects against the pathological behavior of colon cancer cells by interacting with the STAT3 signaling pathway.Experimental and therapeutic medicine · 2020Article
- Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.Journal of neuroinflammation · 2019Article
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- Cimifugin Inhibits Inflammatory Responses of RAW264.7 Cells Induced by Lipopolysaccharide.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis.Journal of neuroinflammation · 2018Article
- The inflammatory response and neuronal injury in Streptococcus suis meningitis.BMC infectious diseases · 2018Article
- Rifampin use in acute community-acquired meningitis in intensive care units: the French retrospective cohort ACAM-ICU study.Critical care (London, England) · 2015Article
- Strategies to increase the activity of microglia as efficient protectors of the brain against infections.Frontiers in cellular neuroscience · 2014Article
- Adjunctive daptomycin attenuates brain damage and hearing loss more efficiently than rifampin in infant rat pneumococcal meningitis.Antimicrobial agents and chemotherapy · 2012Article
- Pathways involved in the synergistic activation of macrophages by lipoteichoic acid and hemoglobin.PloS one · 2012Article
- Pathogenesis and pathophysiology of pneumococcal meningitis.Clinical microbiology reviews · 2011Review
- Animal models of Streptococcus pneumoniae disease.Clinical microbiology reviews · 2008Review
- Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis.Antimicrobial agents and chemotherapy · 2007Article
- Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis.Infection and immunity · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rifampin (RIF) releases smaller quantities of lipoteichoic acids (LTAs) from Streptococcus pneumoniae than ceftriaxone (CRO). Due to the rapid development of resistance, RIF cannot be used as a single agent for therapy of bacterial meningitis. For this reason, we compared the effect of treatment with RIF followed by treatment with CRO (RIF-CRO) or the effect of treatment with clindamycin (CLI) followed by treatment with CRO (CLI-CRO) to that of CRO alone on the concentrations of LTAs and teichoic acids in vitro. The effects of RIF-CRO on LTA concentrations in cerebrospinal fluid (CSF) and on neuronal injury were investigated in a rabbit model of S. pneumoniae meningitis. In vitro, bacterial titers were effectively reduced by CRO, RIF-CRO, and CLI-CRO when each drug was used at 10 micro g/ml. The levels of release of LTAs after the initiation of therapy were lower in RIF-CRO- and CLI-CRO-treated cultures than in cultures treated with CRO alone (P < 0.05 from 3 to 12 h after initiation of treatment). Similarly, in rabbits, the increase in the amount of LTAs in CSF was lower in RIF-CRO-treated animals than in CRO-treated animals (P = 0.02). The density of dentate apoptotic granular cells was lower after RIF-CRO therapy than after CRO therapy (medians, 58.4 and 145.6/mm(2), respectively; 25th quartiles, 36.3 and 81.7/mm(2), respectively; 75th quartiles, 100.7 and 152.3/mm(2), respectively; P = 0.03). Therefore, initiation of therapy with a protein synthesis-inhibiting antibacterial and continuation of therapy with a combination that includes a beta-lactam may be a strategy to decrease neuronal injury in bacterial meningitis.
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