ArticleClinical and experimental immunology2003
Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Double Blind, Placebo Controlled Trial of Albendazole in Soil-Transmitted Helminth and HIV-1 co-Infected Kenyan Individuals to Determine the Effect of Such Treatment on HIV-1 Disease Progression and Genital Shedding.
Empiric Therapy of Helminth Co-infection to Reduce HIV-1 Disease Progression
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Antihelminthics in helminth-endemic areas: effects on HIV disease progression.The Cochrane database of systematic reviews · 2016Pooled it
- Deworming helminth co-infected individuals for delaying HIV disease progression.The Cochrane database of systematic reviews · 2009Pooled it
- Treatment of helminth co-infection in HIV-1 infected individuals in resource-limited settings.The Cochrane database of systematic reviews · 2008Pooled it
- Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature.PLoS neglected tropical diseases · 2007Pooled it
- Albendazole treatment of HIV-1 and helminth co-infection: a randomized, double-blind, placebo-controlled trial.AIDS (London, England) · 2008Trial
- The Epidemiology and Determinants of Opportunistic Intestinal Parasites Among HIV-Positive Patients Attending Care and Treatment Centers in Northcentral Ethiopia.Journal of parasitology research · 2025Article
- Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study.HIV/AIDS (Auckland, N.Z.) · 2021Article
- Chronic Immune Activation and CD4Frontiers in immunology · 2021Review
- Interrogating the Impact of Intestinal Parasite-Microbiome on Pathogenesis of COVID-19 in Sub-Saharan Africa.Frontiers in microbiology · 2021Article
- T lymphocyte subpopulations and intestinal helminthes profile among tuberculosis patients co-infected with HIV before and after anti tubercular treatment at University of Gondar Hospital, Northwest Ethiopia.BMC infectious diseases · 2020Article
- Article
- Immune recovery in HIV-1 infected patients with sustained viral suppression under long-term antiretroviral therapy in Ethiopia.PloS one · 2020Article
- Effect of high-intensity versus low-intensity praziquantel treatment on HIV disease progression in HIV andWellcome open research · 2018Article
- Effect of deworming on Th2 immune response during HIV-helminths co-infection.Journal of translational medicine · 2015Article
- Inflammation and HIV Transmission in Sub-Saharan Africa.Current HIV/AIDS reports · 2015Review
- HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.The Journal of infectious diseases · 2015Article
- Quadruple burden of HIV/AIDS, tuberculosis, chronic intestinal parasitoses, and multiple micronutrient deficiency in ethiopia: a summary of available findings.BioMed research international · 2015Review
- Article
- Article
- Triple NF-kB binding sites and LTR sequence similarities in HIV-1C isolates irrespective of helminth co-infection.Parasites & vectors · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal parasitic infections have been suggested to cause persistent immune activation leading to an unbalanced immune state. Such a state has been proposed to be a major factor in the pathogenesis of AIDS in an African context. The present study investigated the effect of incidental parasitic infection and treatment on the profile of T cell differentiation and activation markers on CD4+ and CD8+ T cells from HIV-1 infected and uninfected adult Ethiopians. Cryopreserved PBMCs from 64 subjects (41 HIV-negative and 23 HIV-positive) with follow-up visits at 6-monthly intervals were used to compare the effect of incidental intestinal parasites and their treatment upon T cell subset profiles and activation status. The samples were stained with antibodies to various T cell differentiation and activation markers allowing naive, memory, effector, memory/effector, activated and resting CD4+ and CD8+ T cell subsets to be quantified by triple-colour FACScan. Incidental intestinal parasitic infections resulted in a significant increase in memory CD4+ T cell numbers both in HIV-negative and HIV-positive subjects (P < 0.05). There was also a significant increase in the percentage of CD8+ HLA-DR+ T cells (P < 0.05) in HIV-positive subjects co-infected with parasites. In HIV-negative subjects, a significant decline in activated cells and a significant increase in resting CD8+ T cells (P < 0.05) was observed after treatment for parasites. These data suggest that intestinal parasitic infections could result in the alteration of T cell subset counts and also in the up-regulation of T cell activation markers in peripheral blood. Treatment of parasitic infections showed a tendency to reduce the activation suggesting that, together with other community based intervention strategies, such treatment could be used to down-regulate immune activation and hence protect the host from being easily attacked by HIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.