ReviewCell stress & chaperones2002
Chaperonin 60 unfolds its secrets of cellular communication.
Review in Cell stress & chaperones, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity.Infection · 2024Pooled it
- Soy Protein-Cultured Mesenchymal Stem Cell-Secreted Extracellular Vesicles Target the Neurovascular Unit: Insights from a Zebrafish Brain Injury Model.ACS biomaterials science & engineering · 2025Article
- GroEL protein of the Leptospira spp. interacts with host proteins and induces cytokines secretion on macrophages.BMC microbiology · 2021Article
- Genes expression profiling of alveolar macrophages exposed to non-functionalized, anionic and cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity.Journal of nanobiotechnology · 2020Article
- The Russian Doll Model: How Bacteria Shape Successful and Sustainable Inter-Kingdom Relationships.Frontiers in microbiology · 2020Review
- Deciphering the Functioning of Microbial Communities: Shedding Light on the Critical Steps in Metaproteomics.Frontiers in microbiology · 2019Article
- Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate.PLoS pathogens · 2018Article
- Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae.Infection and immunity · 2017Article
- Complete genome and gene expression analyses of Asaia bogorensis reveal unique responses to culture with mammalian cells as a potential opportunistic human pathogen.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- Immunolocalization of skeletal matrix proteins in tissue and mineral of the coral Stylophora pistillata.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- B-cell epitopes in GroEL of Francisella tularensis.PloS one · 2014Article
- Molecular stress responses to nano-sized zero-valent iron (nZVI) particles in the soil bacterium Pseudomonas stutzeri.PloS one · 2014Article
- Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis.Genome research · 2012Article
- Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases.Cell stress & chaperones · 2012Review
- Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses.Parasites & vectors · 2011Article
- Article
- Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil.PloS one · 2011Article
- Comparison of the moonlighting actions of the two highly homologous chaperonin 60 proteins of Mycobacterium tuberculosis.Infection and immunity · 2010Article
- GroEL and lipopolysaccharide from Francisella tularensis live vaccine strain synergistically activate human macrophages.Infection and immunity · 2010Article
- The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization.Infection and immunity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell biology of the chaperonins (Cpns) has been intensively studied over the past 25 years. These ubiquitous and essential molecules assist proteins to fold into their native state and function to protect proteins from denaturation after stress. The structure of the most widely studied Cpn60, Escherichia coli GroEL, has been solved and its mechanism of protein folding action largely established. But in the last decade, evidence has accumulated to suggest that the Cpn60s have functions in addition to intracellular protein folding, particularly the ability to act as intercellular signals with a wide variety of biological effects. Cpn60 has the ability to stimulate cells to produce proinflammatory cytokines and other proteins involved in immunity and inflammation and may, therefore, provide a link between innate and adaptive immunity. Cpn60s are also thought to be pathogenic factors in a wide range of diseases and have recently been reported to be present in the circulation of normal subjects and those with heart disease. An interesting facet of these proteins is the finding that in spite of significant sequence conservation, individual Cpn60 proteins can express very different biological activities. This review discusses the work to date, which has revealed the cell-cell signaling actions of Cpn60 proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.