ArticleThe Journal of physiology2003
Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Intracellular calcium release activates carotid body afferents by fentanyl.Function (Oxford, England) · 2026Article
- A switch in kappa opioid receptor signaling from inhibitory to excitatory induced by stress in a subset of cortically-projecting dopamine neurons.bioRxiv : the preprint server for biology · 2025Article
- Article
- Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder.Handbook of experimental pharmacology · 2022Review
- Modulation of serotonin transporter function by kappa-opioid receptor ligands.Neuropharmacology · 2017Article
- Dynorphin-Dependent Reduction of Excitability and Attenuation of Inhibitory Afferents of NPS Neurons in the Pericoerulear Region of Mice.Frontiers in cellular neuroscience · 2016Article
- Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury.The Journal of physiology · 2013Article
- Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Kinase cascades and ligand-directed signaling at the kappa opioid receptor.Psychopharmacology · 2010Review
- Alpha-2 noradrenergic receptor activation inhibits the hyperpolarization-activated cation current (Ih) in neurons of the ventral tegmental area.Neuroscience · 2010Article
- Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Modulators of calcium influx regulate membrane excitability in rat dorsal root ganglion neurons.Anesthesia and analgesia · 2008Article
- Hyperpolarization-activated current (I(h)) contributes to excitability of primary sensory neurons in rats.Brain research · 2008Article
- cAMP-mediated mechanisms for pain sensitization during opioid withdrawal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis.The Journal of physiology · 2004Article
- The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The hyperpolarization-activated current (Ih) is important in the control of resting membrane potential, in the regulation of network firing pattern and in the modulation of presynaptic transmitter release in central neurons. Recent studies on native and cloned Ih channels have demonstrated that the Ih channel is commonly modulated by cAMP through a positive shift in its voltage dependence without a change in its maximum current. The present study demonstrates that activation of kappa-opioid receptors enhances Ih by increasing its maximum current in brainstem neurons in the nucleus raphe magnus. Agents that interfere with the release of intracellular calcium from calcium stores altered the maximum Ih and significantly attenuated the kappa-receptor-mediated enhancement of Ih. These results suggest that kappa-opioid receptors enhance the maximum Ih by mobilizing intracellular calcium from calcium stores. This provides a physiological function for kappa-receptor-stimulated calcium release and may suggest another Ih-regulating mechanism by intracellular calcium in central neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.