ArticleGenes & development2003
A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane.Molecular biology of the cell · 2024Article
- Article
- Characterization of factors that underlie transcriptional silencing in C. elegans oocytes.PLoS genetics · 2023Article
- P-TEFb: The master regulator of transcription elongation.Molecular cell · 2023Review
- Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the wasp Nasonia vitripennis.BMC biology · 2019Article
- Rn7SK small nuclear RNA is involved in cellular senescence.Journal of cellular physiology · 2019Article
- Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.PLoS genetics · 2019Article
- PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the EarlyG3 (Bethesda, Md.) · 2018Article
- Article
- A quiet space during rush hour: Quiescence in primordial germ cells.Stem cell research · 2017Article
- Translational Control of Germ Cell Decisions.Results and problems in cell differentiation · 2017Review
- Germline and Pluripotent Stem Cells.Cold Spring Harbor perspectives in biology · 2015Review
- Repression of somatic cell fate in the germline.Cellular and molecular life sciences : CMLS · 2015Review
- The never-ending story: from pluripotency to plant developmental plasticity.Development (Cambridge, England) · 2015Review
- The biology of the germ line in echinoderms.Molecular reproduction and development · 2014Review
- RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chemical reviews · 2013Review
- Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline.Development (Cambridge, England) · 2013Article
- Transcriptional regulation of gene expression in C. elegans.WormBook : the online review of C. elegans biology · 2013Review
- Polo-like kinase 1 inhibits the activity of positive transcription elongation factor of RNA Pol II b (P-TEFb).PloS one · 2013Article
- Genetics of germ cell development.Nature reviews. Genetics · 2012Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The positive transcription elongation factor b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9). For activating the expression of eukaryotic genes, the histidine-rich sequence in CycT1 binds the heptapeptide repeats in the C-terminal domain (CTD) of RNA polymerase II (RNAPII), whereupon Cdk9 phosphorylates the CTD. We found that alanine-substituted heptapeptide repeats that cannot be phosphorylated also bind CycT1. When placed near transcription units, these CTD analogs block effects of P-TEFb. Remarkably, the transcriptional repressor PIE-1 from Caenorhabditis elegans behaves analogously. It binds CycT1 via an alanine-containing heptapeptide repeat and inhibits transcriptional elongation. Thus, our findings reveal a new mechanism by which repressors inhibit eukaryotic transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.