ReviewGut2003
Haemochromatosis.
Review in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep.Cell & bioscience · 2025Article
- HFE-Related Hemochromatosis May Be a Primary Kupffer Cell Disease.Biomedicines · 2025Review
- Hemochromatosis in an Adult Female With Previous Iron Deficiency Anemia on Iron Supplementation.Cureus · 2023Article
- Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders.Frontiers in neuroscience · 2021Review
- Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication.Molecular and cellular biochemistry · 2020Article
- Improvements in cardiac function detected using echocardiography in patients with hereditary haemochromatosis.Irish journal of medical science · 2020Article
- Assessing the Non-tumorous Liver: Implications for Patient Management and Surgical Therapy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Review
- Coherent and Contradictory Facts, Feats and Fictions Associated with Metal Accumulation in Parkinson's Disease: Epicenter or Outcome, Yet a Demigod Question.Molecular neurobiology · 2017Review
- Finger on the Pulse: Pumping Iron into Chickpea.Frontiers in plant science · 2017Review
- Comparison of clinical MRI liver iron content measurements using signal intensity ratios, RAbdominal radiology (New York) · 2016Article
- Effect of hereditary haemochromatosis genotypes and iron overload on other trace elements.European journal of nutrition · 2013Article
- Redox mechanisms in hepatic chronic wound healing and fibrogenesis.Fibrogenesis & tissue repair · 2008Article
- Analysis of HFE gene mutations and HLA-A alleles in Brazilian patients with iron overload.Sao Paulo medical journal = Revista paulista de medicina · 2006Article
- Where are all the iron men and women?Journal of molecular medicine (Berlin, Germany) · 2003Review
- Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype.Journal of molecular medicine (Berlin, Germany) · 2003Article
- The influence of non-HFE genes and steatohepatitis on increased iron stores in patients with the H63D mutation.Canadian journal of gastroenterology & hepatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an important component of the Earth's crust, but its own chemistry greatly limits utilisation and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration. On the other hand, as humans have no means to control iron excretion, excess iron, regardless of the route of entry, accumulates in parenchymal organs and threatens cell viability. In fact, a number of disease states (that is, iron overload diseases) attributable to genetic or acquired factors are pathogenetically linked to excess body iron stores and iron removal therapy is an effective lifesaving strategy in such circumstances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.