ReviewClinical & experimental metastasis2003
Collapsin response mediator protein-1: a novel invasion-suppressor gene.
Review in Clinical & experimental metastasis, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma.Communications biology · 2025Article
- MonoalleliceLife · 2022Article
- Identification and validation of DNA methylation markers to predict axillary lymph node metastasis of breast cancer.PloS one · 2022Article
- Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer.Translational oncology · 2020Article
- CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex.The Journal of cell biology · 2017Article
- DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.Cancer medicine · 2017Article
- Underexpression of HOXA11 Is Associated with Treatment Resistance and Poor Prognosis in Glioblastoma.Cancer research and treatment · 2017Article
- The biological significance of methylome differences in human papilloma virus associated head and neck cancer.Oncology letters · 2016Article
- Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.Scientific reports · 2016Article
- Article
- Long form collapsin response mediator protein-1 promotes the migration and invasion of osteosarcoma cells.Oncology letters · 2016Article
- Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis.Oncotarget · 2016Article
- Article
- Expression of collapsin response mediator protein 1 in placenta of normal gestation and link to early-onset preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.Topics in current chemistry · 2015Review
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- Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2014Article
- Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review).Oncology letters · 2014Article
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- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-I inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-I mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.