ReviewClinical & experimental metastasis2003
Regulation of cancer metastasis by stress pathways.
Review in Clinical & experimental metastasis, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis.Frontiers in cell and developmental biology · 2021Article
- Article
- Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy.Frontiers in immunology · 2019Article
- Multi-Day Prolonged Low- to Moderate-Intensity Endurance Exercise Mimics Training Improvements in Metabolic and Oxidative Profiles Without Concurrent Chromosomal Changes in Healthy Adults.Frontiers in physiology · 2019Article
- Metabolic Dependencies in Pancreatic Cancer.Frontiers in oncology · 2018Review
- CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis.Scientific reports · 2017Article
- Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?Journal of gastric cancer · 2017Review
- Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity.The Journal of international medical research · 2017Article
- The complex function of hsp70 in metastatic cancer.Cancers · 2013Article
- Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.PloS one · 2013Article
- Evidence of multimeric forms of HSP70 with phosphorylation on serine and tyrosine residues--implications for roles of HSP70 in detection of GI cancers.Asian Pacific journal of cancer prevention : APJCP · 2013Article
- Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1.Cell stress & chaperones · 2012Article
- A case-control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression.BMC cancer · 2012Article
- The interrelating dynamics of hypoxic tumor microenvironments and cancer cell phenotypes in cancer metastasis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells.Neoplasia (New York, N.Y.) · 2012Article
- Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway.Cancer cell · 2012Article
- Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.Molecular cancer · 2012Article
- Growth hormone releasing hormone induces the expression of nitric oxide synthase.Journal of cellular and molecular medicine · 2011Article
- STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer.World journal of gastroenterology · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The presence of activated oncogenes and/or inactivated tumor suppressor genes may result in constitutive activation of multiple transcription factors. This may be especially true in the early stages of tumor development. At advanced stages, however, uncontrolled tumor growth and the consequent development of a stress microenvironment, such as hypoxia, acidosis, and free radical overproduction, may further alter the activity of these transcription factors. Abnormal activation of and interplay between these factors lead to aberrant expression of multiple metastasis-related proteins and confer a tremendous survival and growth advantage to emerging metastatic variants. Understanding the expression and regulation of these molecules may shed more light on the biology of cancer metastasis as well as suggest new preventive and therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.