ReviewRNA (New York, N.Y.)2003
Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA.
Review in RNA (New York, N.Y.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 115 citations in OpenAlex.
- From peptides to DNA: All required steps can be catalyzed.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- How molecular techniques are developed from natural systems.Genetics · 2023Article
- Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications.Advanced healthcare materials · 2019Review
- Rational design of a structure-switching DNA aptamer for potassium ions.FEBS open bio · 2014Article
- In vitro selection of shape-changing DNA nanostructures capable of binding-induced cargo release.ACS nano · 2013Article
- In-silico design of computational nucleic acids for molecular information processing.Journal of cheminformatics · 2013Article
- Oligonucleotide-Based Systems for Input-Controlled and Non-Covalently Regulated Protein-Binding.Supramolecular chemistry · 2013Article
- Structure and mechanism of purine-binding riboswitches.Quarterly reviews of biophysics · 2012Review
- Riboswitches and the RNA world.Cold Spring Harbor perspectives in biology · 2012Review
- Assembly and activation of a kinase ribozyme.RNA (New York, N.Y.) · 2010Article
- Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches.Gene therapy · 2009Review
- Functional nucleic acid sensors.Chemical reviews · 2009Review
- Light-activation of gene function in mammalian cells via ribozymes.Chemical communications (Cambridge, England) · 2009Article
- Leakage and slow allostery limit performance of single drug-sensing aptazyme molecules based on the hammerhead ribozyme.RNA (New York, N.Y.) · 2009Article
- Assay for glucosamine 6-phosphate using a ligand-activated ribozyme with fluorescence resonance energy transfer or CE-laser-induced fluorescence detection.Analytical chemistry · 2008Article
- In vitro selection and characterization of cellulose-binding RNA aptamers using isothermal amplification.Nucleosides, nucleotides & nucleic acids · 2008Article
- RiboaptDB: a comprehensive database of ribozymes and aptamers.BMC bioinformatics · 2006Article
- Characteristics of the glmS ribozyme suggest only structural roles for divalent metal ions.RNA (New York, N.Y.) · 2006Article
- Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay.Nucleic acids research · 2006Article
- Controlling the rate of organic reactions: rational design of allosteric Diels-Alderase ribozymes.Nucleic acids research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Switches and sensors play important roles in our everyday lives. The chemical properties of RNA make it amenable for use as a switch or sensor, both artificially and in nature. This review focuses on recent advances in artificial RNA switches and sensors. Researchers have been applying classical biochemical principles such as allostery in elegant ways that are influencing the development of biosensors and other applications. Particular attention is given here to allosteric ribozymes (aptazymes) that are regulated by small organic molecules, by proteins, or by oligonucleotides. Also discussed are ribozymes whose activities are controlled by various nonallosteric strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.