ArticleProceedings of the National Academy of Sciences of the United States of America2003
Global and specific transcriptional repression by the histone H3 amino terminus in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- DNA Repair in Nucleosomes: Insights from Histone Modifications and Mutants.International journal of molecular sciences · 2024Review
- Mediator, TATA-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast.The Journal of biological chemistry · 2014Article
- Chromatin and transcription in yeast.Genetics · 2012Review
- DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.PLoS genetics · 2012Article
- A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Genetics · 2011Article
- Genome-wide transcriptional dependence on conserved regions of Mot1.Molecular and cellular biology · 2011Article
- Activator-independent transcription of Snf1-dependent genes in mutants lacking histone tails.Molecular microbiology · 2011Article
- Control of chromatin structure by spt6: different consequences in coding and regulatory regions.Molecular and cellular biology · 2011Article
- Evidences for increased expression variation of duplicate genes in budding yeast: from cis- to trans-regulation effects.Nucleic acids research · 2011Article
- Set2-dependent K36 methylation is regulated by novel intratail interactions within H3.Molecular and cellular biology · 2009Article
- Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae.Molecular and cellular biology · 2009Article
- Article
- Dispersed mutations in histone H3 that affect transcriptional repression and chromatin structure of the CHA1 promoter in Saccharomyces cerevisiae.Eukaryotic cell · 2008Article
- Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants.Cell · 2008Article
- Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms.Journal of molecular biology · 2007Article
- Regulation of gene transcription by the histone H2A N-terminal domain.Molecular and cellular biology · 2007Article
- Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability.Molecular and cellular biology · 2007Article
- Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast.Molecular and cellular biology · 2007Article
- Deciphering the roles of the histone H2B N-terminal domain in genome-wide transcription.Molecular and cellular biology · 2006Article
- Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae.Genes & development · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The yeast CHA1 promoter is activated in the presence of serine or threonine. Activation requires the Cha4p activator, and it results in perturbation of a nucleosome that incorporates the TATA element under noninducing conditions. We show that in yeast lacking the amino terminus of histone H3, the promoter is constitutively active and the chromatin is concomitantly perturbed. This derepression occurs in the absence of elevated intracellular levels of serine or threonine and is not observed in cells lacking Rpd3p, Tup1p, or the amino terminus of histone H4. Furthermore, derepression in the absence of the H3 amino terminus requires the primary activator of this promoter, Cha4p, which we show by chromatin immunoprecipitation to be constitutively bound to the CHA1 promoter in WT yeast. Thus, the H3 amino terminus is required to prevent Cha4p from activating CHA1 in the absence of inducer. We also present results of a microarray experiment showing that the H3 amino terminus has a substantial repressive effect on a genome-wide scale.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.