ArticleDigestive diseases and sciences2003
Histological and immunological features of appendix in patients with ulcerative colitis.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Histopathological Findings of Appendix Specimens in Quiescent Ulcerative Colitis: Correlations With Clinical Outcomes in the ACCURE Trial.United European gastroenterology journal · 2026Trial
- Appendoscope-Assisted Endoscopic Retrograde Appendicitis Therapy Versus Antibiotic Monotherapy for Acute Uncomplicated Appendicitis.Digestive diseases and sciences · 2026Article
- Investigating the causal relationship between inflammatory bowel disease and simple appendicitis using Mendelian randomization.Scientific reports · 2024Article
- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- Concomitant occurrence of appendiceal mucocele and ulcerative colitis: Case reports.Caspian journal of internal medicine · 2023Article
- Intestinal ultrasound detects an increased diameter and submucosal layer thickness in the appendix of patients with ulcerative colitis compared to healthy controls - a prospective cohort study.Alimentary pharmacology & therapeutics · 2023Article
- The appendix-mucosal immunity and tolerance in the gut: consequences for the syndromes of appendicitis and its epidemiology.ANZ journal of surgery · 2022Article
- Clinical relevance of endoscopic peri-appendiceal red patch in ulcerative colitis patients.Therapeutic advances in gastroenterology · 2022Article
- Article
- Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study.The American journal of gastroenterology · 2017Article
- The immunology of the vermiform appendix: a review of the literature.Clinical and experimental immunology · 2016Review
- The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms.The American journal of gastroenterology · 2016Review
- The Diagnostic Value of Surface Markers in Acute Appendicitis; A Diagnostic Accuracy Study.Bulletin of emergency and trauma · 2015Article
- Appendiceal skip inflammation and ulcerative colitis.Digestive diseases and sciences · 2014Review
- The vermiform appendix and recurrent Clostridium difficile infection: a curious connection.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2011Article
- Appendiceal Mucocele Detected under Treatment of Ulcerative Colitis.Case reports in gastroenterology · 2009Article
- Appendix is a priming site in the development of ulcerative colitis.World journal of gastroenterology · 2005Article
- Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature.World journal of gastroenterology · 2005Review
- Multiple microcarcinoids in a patient with long standing ulcerative colitis.Journal of clinical pathology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with ulcerative colitis (UC) have a less frequent prior history of appendectomy than the general population. The aim of the present investigation was to elucidate histological and immunological characteristics of the appendix in UC and to assess the effect of appendectomy on the disease. Nine subjects with mildly active UC were treated by surgical appendectomy. In four subjects, the histological findings of the appendix were compatible with ulcerative appendicitis. CD3+CD4+CD25+, CD3+CD4+CD45RO+, and CD3+CD8+CD45RO+ appendiceal mononuclear cells were significantly higher in UC than in acute appendicitis and in normal appendix. There was a trend towards higher mRNA transcripts of IFN-gamma in the appendix of UC than those in other two groups. Clinical activity index decreased significantly four weeks after the appendectomy, although the effect was transient. The appendix is a site of involvement in UC, where mononuclear cells are presumed to be at a state of basal activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.