ArticleDigestive diseases and sciences2003
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- A review on MMP-2 modulating agents from natural and synthetic sources and their role in inflammatory bowel disease.Inflammopharmacology · 2026Review
- Relaxation of mucosal fibronectin fibers in late gut inflammation following neutrophil infiltration in mice.npj biological physics and mechanics · 2025Article
- Prognostic role of tissue plasminogen activator in coronary artery disease with or without aortic valve sclerosis.ESC heart failure · 2023Article
- Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen.Nature communications · 2021Article
- Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk.Digestive diseases and sciences · 2021Article
- Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranesThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2018Article
- Dynamics of M1 macrophages in oral mucosal lesions during the development of acute graft-versus-host disease in rats.Clinical and experimental immunology · 2017Article
- Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases.Gastroenterology research and practice · 2016Article
- NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?Journal of immunology research · 2016Review
- Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure.Clinical oral investigations · 2013Article
- Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats.World journal of gastroenterology · 2012Article
- Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis.World journal of gastroenterology · 2012Article
- The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells.Diabetologia · 2012Article
- Association of MMP-8 polymorphisms with tendinopathy of the primary posterior tibial tendon: a pilot study.Clinics (Sao Paulo, Brazil) · 2011Article
- Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epithelium.Clinical and experimental immunology · 2009Article
- Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.Infection and immunity · 2009Article
- Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- Rat gastric gelatinase induction during endotoxemia.Digestive diseases and sciences · 2006Article
- Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dextran sulfate sodium-induced inflammatory bowel disease in mice resembles human ulcerative colitis. In inflammatory bowel diseases matrix metalloproteinases contribute to tissue degradation. Laminin-5 is an anchoring filament protein in the basement membrane area that can be cleaved by matrix metalloproteinases. We investigated the expression of matrix metalloproteinases-2 and -8 and laminin-5 gamma2-chain in dextran sulfate sodium-induced mice by immunohistochemistry and in situ hybridization. Matrix metalloproteinase-8 expression was evidenced in the colon surface epithelial cells and the protein was more abundant in dextran sulfate sodium-induced mice colon. Matrix metallproteinase-2 and laminin-5 gamma2-chain colocalized in the colon surface epithelial cells and in the basement membrane zone as demonstrated by double immunostaining. In dextran sulfate sodium-induced colon, matrix metalloproteinase-2 immunoreactivity was detected in epithelial cells in the lower parts of the crypt and surrounding the degraded crypts. Matrix metalloproteinase-2 and -8 could participate in the local epithelial inflammatory processes and tissue destruction. The presence of laminin-5 gamma2-chain indicates alternative anchoring mechanisms in the colon, a compartment devoid of hemidesmosomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.