Evidence map›Paper›PMID 12645791›Full record

ArticleDigestive diseases and sciences2003

Neural mechanism of acupuncture-induced gastric relaxations in rats.

Hitoshi Tada, Mikio Fujita, Mary Harris, Makoto Tatewaki, Kazuhiko Nakagawa, Takehira Yamamura, Theodore N Pappas, Toku Takahashi

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Hitoshi TadaDepartment of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Mikio Fujita
Mary Harris
Makoto Tatewaki
Kazuhiko Nakagawa
Takehira Yamamura
Theodore N Pappas
Toku Takahashi
Duke Medical Center · USHyogo Medical University · JP

Funding

ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITYR01DK055808 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAKAHASHI, TOKU · 1999 to 2003
$725k
NIDDK NIH HHS R01 DK55808
6 · The paper itself

Abstract

Acupuncture has been used to treat gastrointestinal symptoms in China for more than 3000 years. However, the mechanism of the beneficial effects of acupuncture remains unknown. Strain gauge transducers were implanted on the serosal surface of the stomach to record circular muscle contractions in thiobutabarbital-anesthetized rats. Acupuncture on the right lower abdomen caused a transient relaxation of the stomach. Acupuncture-induced gastric relaxations were abolished by guanethidine, propranolol, splanchnic ganglionectomy, spinal cord transection, and spinomedullary transection. In contrast, N(G)-nitro-L-arginine, phentolamine, truncal vagotomy, and pontomedullary transection had no effect. Acupuncture increased the number of c-Fos immunopositive cells at the ventrolateral medulla (VLM). It is concluded that acupuncture-induced gastric relaxations are mediated via the somatosympathetic reflex. Its afferent limb is composed of abdominal cutaneous and muscle afferent nerves. Its efferent limb is the gastric sympathetic nerve and the reflex center is within the medulla. VLM neurons may play an important role in mediating this reflex.

Indexed as

AcupunctureAfferent PathwaysAnimalsMaleMuscle ContractionMuscle RelaxationMuscle, SmoothRatsRats, Sprague-DawleyReflexStomach

Identifiers

PMID12645791
OpenAlexW1211322196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.