ArticleHuman genetics2003
Examination of sequence homology between human chromosome 20 and the mouse genome: intense conservation of many genomic elements.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Article
- Transposable elements as scaffold/matrix attachment regions: shaping organization and functions in genomes.Frontiers in molecular biosciences · 2023Article
- Temporal transcriptomic analysis of metabolic genes in maternal organs and placenta during murine pregnancy.Biology of reproduction · 2018Article
- Differences between Mice and Humans in Regulation and the Molecular Network of Collagen, Type III, Alpha-1 at the Gene Expression Level: Obstacles that Translational Research Must Overcome.International journal of molecular sciences · 2015Article
- A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.BMC systems biology · 2010Article
- Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A novel mouse Chromosome 2 congenic strain with obesity phenotypes.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conservation of genomic organization of mammalian species has been of interest for its usefulness in characterizing the genetics of traits and diseases and as one tool for examining evolution. The recent rough draft sequencing of the mouse and human genomes provides the opportunity for more detailed analyses. The current study examines the extent of homology between human chromosome 20 and the mouse genome by comparing putative coding and non-coding sequence to provide insight into organizational and sequence similarities between the species. The relative position of each of 460 putative coding orthologues was the same in both species, except for a single genomic segment rearrangement. The similarity extended to exon/intron structure, the size of introns, as well as strong evidence for the conservation of position of ancient LINE-1, LINE-2 and LTR repetitive sequence and the subtelomeric region of the long arm of human chromosome 20 and that of mouse chromosome 2. There was also evidence for conservation of a limited amount of non-coding single-copy sequence. Together these data provide additional insight into the extent of conservation of mammalian genomic organization and sequence.
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Registered trials
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