ReviewBritish journal of cancer2003
Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy.
Review in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Prognostic Role of Neutrophil/Lymphocyte Ratio in Resected Gastric Cancer: A Systematic Review and Meta-analysis.Clinics (Sao Paulo, Brazil) · 2018Pooled it
- Anticancer potential of Carica papaya Linn black seed extract against human colon cancer cell line: in vitro study.BMC complementary medicine and therapies · 2023Article
- Protective potential of piroxicam on human peripheral blood mononuclear cells against the suppressive capacity of glioblastoma cell lines.Scientific reports · 2022Article
- Small Molecular Drug Screening Based on Clinical Therapeutic Effect.Molecules (Basel, Switzerland) · 2022Article
- CMTM6 expression in M2 macrophages is a potential predictor of PD-1/PD-L1 inhibitor response in colorectal cancer.Cancer immunology, immunotherapy : CII · 2021Article
- Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective.Biochemical pharmacology · 2020Review
- Over-Expression of Cyclooxygenase-2 in Colorectal Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma.Acta pharmaceutica Sinica. B · 2019Article
- Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers.Frontiers in oncology · 2019Review
- Colon targeted beads loaded with pterostilbene: Formulation, optimization, characterization andSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships.Bioorganic & medicinal chemistry letters · 2018Article
- Biochanin A extirpates the epithelial-mesenchymal transition in a human lung cancer.Experimental and therapeutic medicine · 2018Article
- Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs.Scientific reports · 2018Article
- Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway.Clinical and translational medicine · 2017Review
- Inferring active regulatory networks from gene expression data using a combination of prior knowledge and enrichment analysis.BMC bioinformatics · 2016Article
- HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.Inflammation · 2016Article
- Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer.International journal of oncology · 2016Article
- Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression.Physiological reports · 2014Article
- Article
- Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.Familial cancer · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, we discuss the available experimental evidences supporting the chemopreventive efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) on colorectal cancer and the biological basis for their possible role as anticancer agents. Although the comprehension of the mechanisms underlying the effects of these drugs on colon cancer cells is incomplete, research efforts in identifying the biochemical pathway by which NSAIDs exert their chemopreventive effect have provided a rationale for the potential use of NSAIDs alone or in combination with conventional and experimental anticancer agents in the treatment of colorectal cancer. In this paper, we review three main issues: (i) the role of COX-2 in colon cancer; (ii) the common death pathways between NSAIDs and anticancer drugs; and (iii) the biological basis for the combination therapy with COX-2 selective inhibitors and new selective inhibitors of growth factor signal transduction pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.