ArticlePlant physiology2003
One-carbon metabolism in plants. Regulation of tetrahydrofolate synthesis during germination and seedling development.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 160 citations in OpenAlex.
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- Linking cellular metabolism to chromatin modifications in plants.Journal of integrative plant biology · 2026Review
- Development of an improved construct for spectinomycin selection in plant transformation.BMC research notes · 2025Article
- Genome and transcriptome wide association study identify candidate genes regulating folate levels in maize.Frontiers in plant science · 2025Article
- Multi-omic analysis of the extension of broccoli quality during storage by folic acid.Journal of advanced research · 2024Article
- Identification and validation of seed dormancy loci and candidate genes and construction of regulatory networks by WGCNA in maize introgression lines.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Application of Methionine Increases the Germination Rate of Maize Seeds by Triggering Multiple Phenylpropanoid Biosynthetic Genes at Transcript Levels.Plants (Basel, Switzerland) · 2023Article
- Comparative genomic analysis ofMicrobial genomics · 2023Article
- Metabolic network changes during skotomorphogenesis inPlant direct · 2022Article
- Folic Acid Reinforces Maize Tolerance to Sodic-Alkaline Stress through Modulation of Growth, Biochemical and Molecular Mechanisms.Life (Basel, Switzerland) · 2022Article
- Folic Acid Confers Tolerance against Salt Stress-Induced Oxidative Damages in Snap Beans through Regulation Growth, Metabolites, Antioxidant Machinery and Gene Expression.Plants (Basel, Switzerland) · 2022Article
- Comparative Transcriptome Analysis Reveals Mechanisms of Folate Accumulation in Maize Grains.International journal of molecular sciences · 2022Article
- A genome-wide association study of folates in sweet corn kernels.Frontiers in plant science · 2022Article
- Red light enhances folate accumulation in wheat seedlings.Journal of Zhejiang University. Science. B · 2021Article
- Genetic and physiological regulation of folate in pak choi (Brassica rapa subsp. Chinensis) germplasm.Journal of experimental botany · 2020Article
- Influence of Sulfonamide Contamination Derived from Veterinary Antibiotics on Plant Growth and Development.Antibiotics (Basel, Switzerland) · 2020Article
- Development of a nornicotine-reduced flue-cured tobacco line via EMS mutagenesis of nicotine N-demethylase genes.Plant signaling & behavior · 2020Article
- Flours from Swedish pulses: Effects of treatment on functional properties and nutrient content.Food science & nutrition · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tetrahydrofolate (THF) is a central cofactor for one-carbon transfer reactions in all living organisms. In this study, we analyzed the expression of dihydropterin pyrophosphokinase-dihydropteroate synthase (HPPK-DHPS) in pea (Pisum sativum) organs during development, and so the capacity to synthesize dihydropteroate, an intermediate in the de novo THF biosynthetic pathway. During seedling development, all of the examined organs/tissues contain THF coenzymes, collectively termed folate, and express the HPPK-DHPS enzyme. This suggests that each organ/tissue is autonomous for the synthesis of THF. During germination, folate accumulates in cotyledons and embryos, but high amounts of HPPK-DHPS are only observed in embryos. During organ differentiation, folate is synthesized preferentially in highly dividing tissues and in photosynthetic leaves. This is associated with high levels of the HPPK-DHPS mRNA and protein, and a pool of folate 3- to 5-fold higher than in the rest of the plant. In germinating embryos and in meristematic tissues, the high capacity to synthesize and accumulate folate correlates with the general resumption of cell metabolism and the high requirement for nucleotide synthesis, major cellular processes involving folate coenzymes. The particular status of folate synthesis in leaves is related to light. Thus, when illuminated, etiolated leaves gradually accumulate the HPPK-DHPS enzyme and folate. This suggests that folate synthesis plays an important role in the transition from heterotrophic to photoautotrophic growth. Analysis of the intracellular distribution of folate in green and etiolated leaves indicates that the coenzymes accumulate mainly in the cytosol, where they can supply the high demand for methyl groups.
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