ArticlePlant physiology2003
The Medicago species A2-type cyclin is auxin regulated and involved in meristem formation but dispensable for endoreduplication-associated developmental programs.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 99 citations in OpenAlex.
- Genome-wide cyclin gene evolution in Arabidopsis and Brassica reveals polyploidization-driven duplication and flowering-time associations.Molecular genetics and genomics : MGG · 2026Article
- Diverse triggers, common outcome: Senescence in Fix⁻ Medicago truncatula nodules.Plant physiology · 2025Article
- Visualization of the Crossroads between a Nascent Infection Thread and the First Cell Division Event inInternational journal of molecular sciences · 2022Article
- SHORT-ROOT paralogs mediate feedforward regulation of D-type cyclin to promote nodule formation in soybean.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Auxin regulated metabolic changes underlying sepal retention and development after pollination in spinach.BMC plant biology · 2021Article
- Genome-wide association studies in tropical maize germplasm reveal novel and known genomic regions for resistance to Northern corn leaf blight.Scientific reports · 2020Article
- Genome-Wide Analysis of the Cyclin Gene Family and Their Expression Profile inInternational journal of molecular sciences · 2020Article
- Overexpression ofInternational journal of molecular sciences · 2019Article
- Analysis of Differentially Expressed Genes in Tissues of Camellia sinensis during Dedifferentiation and Root Redifferentiation.Scientific reports · 2019Article
- Transcriptional profiling identifies critical steps of cell cycle reprogramming necessary for Plasmodiophora brassicae-driven gall formation in Arabidopsis.The Plant journal : for cell and molecular biology · 2019Article
- Article
- A DII Domain-Based Auxin Reporter Uncovers Low Auxin Signaling during Telophase and Early G1.Plant physiology · 2017Article
- Respiratory Burst Oxidase Homolog Gene A Is Crucial forFrontiers in plant science · 2017Article
- Spatial Regulation of Root Growth: Placing the Plant TOR Pathway in a Developmental Perspective.International journal of molecular sciences · 2015Review
- Interaction and signalling between a cosmopolitan phytoplankton and associated bacteria.Nature · 2015Article
- Molecular functions of genes related to grain shape in rice.Breeding science · 2015Review
- Genome-wide identification and expression analysis of auxin response factor gene family in Medicago truncatula.Frontiers in plant science · 2015Article
- Role of auxin during intercellular infection of Discaria trinervis by Frankia.Frontiers in plant science · 2014Article
- Nitrogen-fixing Rhizobium-legume symbiosis: are polyploidy and host peptide-governed symbiont differentiation general principles of endosymbiosis?Frontiers in microbiology · 2014Review
- The non-specific lipid transfer protein N5 of Medicago truncatula is implicated in epidermal stages of rhizobium-host interaction.BMC plant biology · 2012Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytohormones as well as temporal and spatial regulation of the cell cycle play a key role in plant development. Here, we investigated the function and regulation of an alfalfa (Medicago sativa) A2-type cyclin in three distinct root developmental programs: in primary and secondary root development, nodule development, and nematode-elicited gall formation. Using transgenic plants carrying the Medsa;cycA2;2 promoter-beta-glucuronidase gene fusion, in combination with other techniques, cycA2;2 expression was localized in meristems and proliferating cells in the lateral root and nodule primordia. Rapid induction of cycA2;2 by Nod factors demonstrated that this gene is implicated in cell cycle activation of differentiated cells developing to nodule primordia. Surprisingly, cycA2;2 was repressed in the endoreduplicating, division-arrested cells both during nodule development and formation of giant cells in nematode-induced galls, indicating that CycA2;2 was dispensable for S-phase in endoreduplication cycles. Overexpression of cycA2;2 in transgenic plants corresponded to wild type protein levels and had no apparent phenotype. In contrast, antisense expression of cycA2;2 halted regeneration of somatic embryos, suggesting a role for CycA2;2 in the formation or activity of apical meristems. Expression of cycA2;2 was up-regulated by auxins, as expected from the presence of auxin response elements in the promoter. Moreover, auxin also affected the spatial expression pattern of this cyclin by shifting the cycA2;2 expression from the phloem to the xylem poles.
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