ArticlePlant physiology2003
Nod factor elicits two separable calcium responses in Medicago truncatula root hair cells.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 175 citations in OpenAlex.
- Rhizobial Nod factors modulate reactive oxygen species, jasmonates, and pattern-recognizing receptors to suppress immune response.Plant molecular biology · 2026Article
- A plant Lysin Motif Receptor-Like Kinase plays an ancestral function in mycorrhiza.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Legumes Regulate Symbiosis with Rhizobia via Their Innate Immune System.International journal of molecular sciences · 2023Review
- TETRASPANIN 8-1 fromFrontiers in plant science · 2023Article
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- The Role of Heterotrimeric G-Protein Beta Subunits During Nodulation inFrontiers in plant science · 2021Article
- Calcium spikes, waves and oscillations in plant development and biotic interactions.Nature plants · 2020Review
- What Drives Symbiotic Calcium Signalling in Legumes? Insights and Challenges of Imaging.International journal of molecular sciences · 2019Review
- Structural Variations in LysM Domains of LysM-RLKInternational journal of molecular sciences · 2019Article
- Identification and mapping of two independent recessive loci for the root hairless mutant phenotype in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Differential tetraspanin genes expression and subcellular localization during mutualistic interactions in Phaseolus vulgaris.PloS one · 2019Article
- Dual Color Sensors for Simultaneous Analysis of Calcium Signal Dynamics in the Nuclear and Cytoplasmic Compartments of Plant Cells.Frontiers in plant science · 2018Article
- Article
- A role for the mevalonate pathway in early plant symbiotic signaling.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Genome-wide identification of CAMTA gene family members in Medicago truncatula and their expression during root nodule symbiosis and hormone treatments.Frontiers in plant science · 2015Article
- Host-specific Nod-factors associated with Medicago truncatula nodule infection differentially induce calcium influx and calcium spiking in root hairs.The New phytologist · 2013Article
- Towards the Physics of Calcium Signalling in Plants.Plants (Basel, Switzerland) · 2013Review
- Rhizobial and mycorrhizal symbioses in Lotus japonicus require lectin nucleotide phosphohydrolase, which acts upstream of calcium signaling.Plant physiology · 2013Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulation of intracellular calcium levels plays a key role in the transduction of many biological signals. Here, we characterize early calcium responses of wild-type and mutant Medicago truncatula plants to nodulation factors produced by the bacterial symbiont Sinorhizobium meliloti using a dual-dye ratiometric imaging technique. When presented with 1 nM Nod factor, root hair cells exhibited only the previously described calcium spiking response initiating 10 min after application. Nod factor (10 nM) elicited an immediate increase in calcium levels that was temporally earlier and spatially distinct from calcium spikes occurring later in the same cell. Nod factor analogs that were structurally related, applied at 10 nM, failed to initiate this calcium flux response. Cells induced to spike with low Nod factor concentrations show a calcium flux response when Nod factor is raised from 1 to 10 nM. Plant mutants previously shown to be deficient for the calcium spiking response (dmi1 and dmi2) exhibited an immediate, truncated calcium flux with 10 nM Nod factor, demonstrating a competence to respond to Nod factor but an impaired ability to generate a full biphasic response. These results demonstrate that the legume root hair cell exhibits two independent calcium responses to Nod factor triggered at different agonist concentrations and suggests an early branch point in the Nod factor signal transduction pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.