ReviewCurrent diabetes reports2001
Genetics of diabetic nephropathy in the Pima Indians.
Review in Current diabetes reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The association of genetic variants of type 2 diabetes with kidney function.Kidney international · 2012Pooled it
- Sociodemographic determinants of chronic kidney disease in Indigenous children.Pediatric nephrology (Berlin, Germany) · 2022Review
- Aquaporin 11 variant associates with kidney disease in type 2 diabetic patients.American journal of physiology. Renal physiology · 2016Article
- Article
- Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.Endocrine research · 2013Article
- Prevalence, determinants and co-morbidities of chronic kidney disease among First Nations adults with diabetes: results from the CIRCLE study.BMC nephrology · 2012Article
- ELMO1 variants and susceptibility to diabetic nephropathy in American Indians.Molecular genetics and metabolism · 2010Article
- Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms.Nature reviews. Nephrology · 2010Review
- The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study.American journal of hypertension · 2009Article
- Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains.American journal of physiology. Renal physiology · 2009Article
- Aldose reductase genotypes and cardiorenal complications: an 8-year prospective analysis of 1,074 type 2 diabetic patients.Diabetes care · 2008Article
- A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2008Article
- Heritability of the severity of diabetic retinopathy: the FIND-Eye study.Investigative ophthalmology & visual science · 2008Article
- Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach.Diabetologia · 2007Article
- Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.Human genetics · 2005Article
- Type 2 diabetes mellitus and its complications: from the molecular biology to the clinical practice.The review of diabetic studies : RDS · 2004Article
- Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles.Molecular and cellular biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Diabetic nephropathy is the leading cause of renal failure in industrialized countries. There is strong evidence that diabetic nephropathy is influenced by genetic factors. Studies in the Pima Indians as well as in other populations demonstrate that diabetic nephropathy aggregates in families. The hypothesis that the familial aggregation reflects the effect of a major gene was formally tested by segregation analysis of diabetic nephropathy in Pima Indians with type 2 diabetes. The segregation analysis provided strong evidence for a major genetic effect on the prevalence of diabetic nephropathy; this suggests that some of the genetic determinants of diabetic nephropathy may have effects of sufficient magnitude to be detected by linkage analysis. Therefore, we analyzed data from a genome-wide scan to identify susceptibility loci for nephropathy in diabetic Pima Indians. Analyses conducted by both parametric (model-based) and nonparametric methods revealed tentative evidence for nephropathy susceptibility loci on chromosomes 3q, 7q, 18q, and 20p.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.