ReviewCurrent diabetes reports2002
Autoimmunity and familial risk of type 1 diabetes.
Review in Current diabetes reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Review of nonpharmacological interventions for delaying the effects of cerebral neuropathy caused by diabetes.Frontiers in endocrinology · 2025Review
- The risk of Type 1 diabetes in children born after ART: a Nordic cohort study from the CoNARTaS group.Human reproduction open · 2024Article
- Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample.Biomedicines · 2023Article
- Type 1 diabetes mellitus in pediatric age group: A rising endemic.Journal of family medicine and primary care · 2022Review
- Type 1 Diabetes incidence among youth in Utah: A geographical analysis.Social science & medicine (1982) · 2021Article
- Targeting Glycoproteins as a therapeutic strategy for diabetes mellitus and its complications.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Review
- Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?Pediatric diabetes · 2018Article
- Review
- Challenges in diagnosis and management of diabetes in the young.Clinical diabetes and endocrinology · 2016Review
- Type 1 diabetes: A predictable disease.World journal of diabetes · 2015Review
- Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.Rheumatic diseases clinics of North America · 2014Review
- The pathogenesis and natural history of type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
- Epidemiology of type 1 diabetes.Endocrinology and metabolism clinics of North America · 2010Review
- Article
- Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation.Transplantation · 2008Article
- Environmental factors in the development of Type 1 diabetes.Reviews in endocrine & metabolic disorders · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence that the process leading to type I diabetes may start in early infancy or already in utero. Even though diabetes-associated antibodies can be detected in up to half of the pregnancies of mothers with type I diabetes, pregnancy itself has no major effect on these antibodies. If such antibodies are present in the mother, they are transferred to the fetal circulation and are detectable in cord blood. Most of the transplacentally transferred antibodies disappear by 6 months of age, but may persist even longer. Antibodies present in cord blood may represent true induction of beta-cell autoimmunity, but such a phenomenon is extremely rare. The offspring of affected mothers have a 2% to 3% risk of type I diabetes, which is about one third of that in the offspring of affected fathers. A novel conceivable explanation is that exogenous insulin transplacentally transferred in immune complexes might lead to the induction of tolerance to insulin, which may be the primary autoantigen in type I diabetes. The possible protective or predisposing effect of diabetes-associated antibodies detectable at birth on progression to clinical type I diabetes later will be assessed in ongoing prospective birth cohort studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.