ReviewCurrent diabetes reports2002
Endothelium, inflammation, and diabetes.
Review in Current diabetes reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 87 citations in OpenAlex.
- Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression.The American journal of clinical nutrition · 2010Trial
- AMPK-Dependent YAP Inhibition Mediates the Protective Effect of Metformin against Obesity-Associated Endothelial Dysfunction and Inflammation.Antioxidants (Basel, Switzerland) · 2023Article
- Dementia in Diabetes: The Role of Hypoglycemia.International journal of molecular sciences · 2023Review
- Soluble and insoluble protein aggregates, endoplasmic reticulum stress, and vascular dysfunction in Alzheimer's disease and cardiovascular diseases.GeroScience · 2023Review
- Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases.International journal of molecular sciences · 2022Review
- Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?Experimental neurology · 2020Review
- TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.American journal of respiratory cell and molecular biology · 2019Article
- Perioperative Management of Hyperglycemia and Diabetes in Cardiac Surgery Patients.Endocrinology and metabolism clinics of North America · 2018Review
- Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2017Review
- Diabetes mellitus and cognitive impairments.World journal of diabetes · 2016Review
- Insulin dysfunction and Tau pathology.Frontiers in cellular neuroscience · 2014Review
- Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease.Frontiers in endocrinology · 2014Review
- Type 2 diabetes and cognitive compromise: potential roles of diabetes-related therapies.Endocrinology and metabolism clinics of North America · 2013Review
- Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats.Probiotics and antimicrobial proteins · 2011Article
- Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis.Journal of cellular and molecular medicine · 2011Review
- Management of hyperglycemia in hospitalized patients.Annals of the New York Academy of Sciences · 2010Review
- Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals.Diabetes care · 2010Article
- Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2008Article
- High glucose and Nepsilon-(carboxymethyl) lysine bovine serum albumin modulate release of matrix metalloproteinases in cultured human endothelial cells.European journal of nutrition · 2006Article
- Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.Current diabetes reports · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory, and thus are potentially antiatherogenic. It has recently been noted that insulin stimulates NO release by the endothelium. Insulin is a vasodilator, has antiplatelet activity, and is anti-inflammatory. Similar anti-inflammatory effects of thiazolidinediones (TZDs), troglitazone and rosiglitazone, suggest that they too may have potential antiatherogenic effects. These effects of insulin and TZDs are important because the two major states of insulin resistance, obesity and type 2 diabetes, are associated with a marked increase in atherosclerosis coronary heart disease, and stroke. These recent observations have extremely momentous implications for the understanding of the pathogenesis of atherosclerosis in insulin-resistant states and for a rational approach to their comprehensive treatment, including the prevention of atherosclerosis and its complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.