ArticleOncogene2003
Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Integrated Multi-Omics and Spatial Transcriptomics Reveal GUK1 as a Prognostic Biomarker Regulated by the TP53-HSF1 Axis in Breast Cancer.Oncology research · 2026Article
- Can social adversity alter the epigenome, trigger oral disease, and affect future generations?Irish journal of medical science · 2024Review
- Roles of the NR2F Family in the Development, Disease, and Cancer of the Lung.Journal of developmental biology · 2024Review
- A non-mutatedFrontiers in oncology · 2023Article
- Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside.Experimental hematology & oncology · 2022Review
- Article
- Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal Transition.Biomolecules · 2021Review
- PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.Journal of cellular and molecular medicine · 2020Article
- Biology and clinical relevance of EpCAM.Cell stress · 2019Review
- Pharmacogenetic and pharmacogenomic discovery strategies.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- Significant associations between driver gene mutations and DNA methylation alterations across many cancer types.PLoS computational biology · 2017Article
- p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading.BMC cancer · 2016Article
- Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites.Nucleic acids research · 2016Article
- Epigenetic inheritance and the missing heritability.Human genomics · 2015Review
- Article
- TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma.Molecular cancer · 2015Article
- Epigenetic heredity of human height.Physiological reports · 2014Article
- Article
- Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion.Cancer research · 2009Article
- Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 and DNA methylation play key roles in the maintenance of genome stability. In this work, we demonstrate that the two mechanisms are linked and that p53 plays a role in the maintenance of the DNA methylation levels. The loss of p53 was shown to induce loss of DNA methylation in the TROP1 gene, a human cancer-expressed locus that undergoes amplification when hypomethylated. This demethylation was reverted by the reintroduction of a wild-type TP53 (wtTP53) in the TP53-null cells. Using a gene-amplification assay in vivo, we demonstrate that the loss of p53 leads to a demethylation-dependent TROP1 gene amplification. The induction of gene amplification was reverted by the expression of a wtTP53 gene or by in vitro methylation of the transfected DNA with the Sss I DNA methylase. Taken together, these findings demonstrate that the inactivation of TP53 induces loss of DNA methylation and DNA methylation-dependent gene amplification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.