ArticleProceedings of the National Academy of Sciences of the United States of America2003
ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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122 citing papers in PubMed, 291 citations in OpenAlex.
- Visualization of the chloroplast MinE ring in living mesophyll cells ofPlant signaling & behavior · 2026Article
- Plant organelle division orchestrated by the mosaic machinery of endosymbiotic relics and eukaryotic host factors.Plant physiology · 2026Review
- Size of chloroplasts in Arabidopsis mesophyll cells affects jasmonate biosynthesis.Plant biology (Stuttgart, Germany) · 2026Article
- A multiplant transcriptomic atlas reveals conserved and lineage-specific defense architectures in response toProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Crosstalk of heat shock proteins and antioxidants with peroxisome biogenesis supports wheat thermotolerance.Scientific reports · 2026Article
- The segregation of organelles and organellar genomes across eukaryotic biology.Biochemical Society transactions · 2026Review
- Simultaneous defects in chloroplast development and division cause leaf variegation in Arabidopsis.Plant communications · 2026Article
- The dynamin-related proteinFrontiers in plant science · 2026Article
- Binary division of plastids involves endoplasmic reticulum mediation.Journal of experimental botany · 2025Article
- Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Uncovering the genetic mechanism of rind color trait in watermelon using fine mapping and comparative transcriptomic analysis.Frontiers in plant science · 2025Article
- Auxin promotes chloroplast division by increasing the expression of chloroplast division genes.Plant cell reports · 2024Article
- Principles of amyloplast replication in the ovule integuments of Arabidopsis thaliana.Plant physiology · 2024Article
- Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.bioRxiv : the preprint server for biology · 2024Article
- Article
- Analysis of morphological traits and regulatory mechanism of a semi-dwarf, albino, and blue grain wheat line.Molecular breeding : new strategies in plant improvement · 2023Article
- SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features.Nature communications · 2023Article
- Improvements for Tissue-Chopping-Based Immunofluorescence Staining Method of Chloroplast Proteins.Plants (Basel, Switzerland) · 2023Article
- Comparative physiology and transcriptome analysis reveals that chloroplast development influences silver-white leaf color formation in Hydrangea macrophylla var. maculata.BMC plant biology · 2022Article
62 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Chloroplast division in plant cells is orchestrated by a complex macromolecular machine with components positioned on both the inner and outer envelope surfaces. The only plastid division proteins identified to date are of endosymbiotic origin and are localized inside the organelle. Employing positional cloning methods in Arabidopsis in conjunction with a novel strategy for pinpointing the mutant locus, we have identified a gene encoding a new chloroplast division protein, ARC5. Mutants of ARC5 exhibit defects in chloroplast constriction, have enlarged, dumbbell-shaped chloroplasts, and are rescued by a wild-type copy of ARC5. The ARC5 gene product shares similarity with the dynamin family of GTPases, which mediate endocytosis, mitochondrial division, and other organellar fission and fusion events in eukaryotes. Phylogenetic analysis showed that ARC5 is related to a group of dynamin-like proteins unique to plants. A GFP-ARC5 fusion protein localizes to a ring at the chloroplast division site. Chloroplast import and protease protection assays indicate that the ARC5 ring is positioned on the outer surface of the chloroplast. Thus, ARC5 is the first cytosolic component of the chloroplast division complex to be identified. ARC5 has no obvious counterparts in prokaryotes, suggesting that it evolved from a dynamin-related protein present in the eukaryotic ancestor of plants. These results indicate that the chloroplast division apparatus is of mixed evolutionary origin and that it shares structural and mechanistic similarities with both the cell division machinery of bacteria and the dynamin-mediated organellar fission machineries of eukaryotes.
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