ArticleBritish journal of pharmacology2003
Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- Emerging pharmacological targets in overactive bladder therapy: experimental and clinical evidences.International urogynecology journal and pelvic floor dysfunction · 2008Pooled it
- Calcium Signaling Dynamics in Vascular Cells and Their Dysregulation in Vascular Disease.Biomolecules · 2025Review
- Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions.American journal of physiology. Renal physiology · 2023Article
- The role of rhoA/rho-kinase and PKC in the inhibitory effect of L-cysteine/HNaunyn-Schmiedeberg's archives of pharmacology · 2023Article
- The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.American journal of physiology. Cell physiology · 2023Article
- The effect of testosterone replacement therapy on bladder functions, histology, apoptosis, and Rho-kinase expression in bladder outlet obstruction and hypogonadism rat modelTurkish journal of medical sciences · 2021Article
- Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle.Frontiers in medicine · 2021Article
- Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease.Biochemical pharmacology · 2018Review
- Rho kinase inhibition ameliorates cyclophosphamide-induced cystitis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Regulation of pulmonary endothelial barrier function by kinases.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle.BMC urology · 2015Article
- Aging changes agonist induced contractile responses in permeabilized rat bladder.Age (Dordrecht, Netherlands) · 2015Article
- Protective Effect and Mechanism of Total Flavones from Rhododendron simsii Planch Flower on Cultured Rat Cardiomyocytes with Anoxia and Reoxygenation.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.Physiological reviews · 2014Review
- Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.Acta pharmacologica Sinica · 2014Article
- Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.Cardiovascular diabetology · 2013Article
- PDE5-Is for the Treatment of Concomitant ED and LUTS/BPH.Current bladder dysfunction reports · 2013Article
- The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Sensory dysfunction of bladder mucosa and bladder oversensitivity in a rat model of metabolic syndrome.PloS one · 2012Article
- Plasticity of non-adrenergic non-cholinergic bladder contractions in rats after chronic spinal cord injury.Brain research bulletin · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) The involvement of Rho-kinase (ROCK) in the contractile mechanisms mediating smooth muscle contraction of the rat urinary bladder was investigated using expression studies and the ROCK inhibitor Y-27632. (2) Both isoforms of ROCK (ROCK I and ROCK II) were detected in high levels in rat urinary bladder. (3) Y-27632 (10 micro M) significantly attenuated contractions of rat urinary bladder strips evoked by the G-protein coupled receptor agonists carbachol (58.1+/-10.5% at 0.3 micro M) and neurokinin A (68.6+/-12.7% at 1 micro M) without affecting contractions to potassium chloride (10-100 mM). In addition, basal tone was reduced by 47.8+/-2.0% by 10 micro M Y-27632 in the absence of stimulation. (4) Contractions of urinary bladder strips evoked by the P2X receptor agonist alpha,beta-methylene ATP (alpha,beta-mATP; 10 micro M) were also attenuated by Y-27632 (30.0+/-7.2% at 10 micro M). (5) Y-27632 (10 micro M) significantly attenuated contractions evoked by electrical field stimulation (2-16 Hz). The effect of Y-27632 on the tonic portion of the neurogenic response (4-16 Hz) was not significantly different from the effect of atropine (1 micro M) alone. (6) While the mechanism underlying the ability of Y-27632 to inhibit alpha,beta-mATP-evoked contractions remains undetermined, the results of the present study clearly demonstrate a role for ROCK in the regulation of rat urinary bladder smooth muscle contraction and tone.
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