ArticleMolecular and cellular biology2003
Changes in histone acetylation are associated with differences in accessibility of V(H) gene segments to V-DJ recombination during B-cell ontogeny and development.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 114 citations in OpenAlex.
- Germline-encoded recognition of peanut underlies development of convergent antibodies in humans.Science translational medicine · 2025Article
- Non-canonical functions of enhancers: regulation of RNA polymerase III transcription, DNA replication, and V(D)J recombination.Trends in genetics : TIG · 2024Article
- Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes.Cell reports · 2023Article
- IL-7R signaling activates widespread VCell reports · 2021Article
- Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.Cellular & molecular immunology · 2019Article
- Review
- Dissecting Epigenetic Dysregulation of Primary Antibody Deficiencies.Journal of clinical immunology · 2016Review
- Biased Immunoglobulin Light Chain Gene Usage in the Shark.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire.BMC immunology · 2014Article
- Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination.The EMBO journal · 2013Article
- Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment.PLoS biology · 2012Article
- A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Epigenetic regulation of antigen receptor gene rearrangement.Current opinion in immunology · 2011Review
- The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.The Journal of biological chemistry · 2010Article
- Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.Nature immunology · 2010Article
- Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.Molecular and cellular biology · 2009Article
- RAG: a recombinase diversified.Nature immunology · 2009Review
- A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.The Journal of experimental medicine · 2009Article
- The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Although V(D)J recombination is thought to be regulated by changes in the accessibility of chromatin to the recombinase machinery, the mechanisms responsible for establishing "open" chromatin are poorly understood. We performed a detailed study of the acetylation status of histones associated with 11 V(H) gene segments, their flanking regions, and various intergenic elements during B-cell development and ontogeny, when V(D)J recombination is highly regulated. Histone H4 shows higher and more-regulated acetylation than does histone H3 in the V(H) locus. In adult pro-B cells, V(H) gene segments are acetylated prior to V(D)J rearrangement, with higher acetylation associated with J(H)-distal V(H) gene segments. While large regions of the V(H) locus have similar patterns of histone acetylation, acetylation is narrowly confined to the gene segments, their flanking promoters, and recombinase signal sequence elements. Thus, histone acetylation in the V(H) locus is both locally and globally regulated. Increased histone acetylation accompanies preferential recombination of J(H)-proximal V(H) gene segments in early B-cell ontogeny, and decreased histone acetylation accompanies inhibition of V-DJ recombination in a transgenic model of immunoglobulin heavy-chain allelic exclusion. Thus, changes in histone acetylation appear to be important for both promotion and inhibition of V-DJ rearrangement during B-cell ontogeny and development.
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Registered trials
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