ArticleMolecular and cellular biology2003
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Inflammatory Networks in Renal Cell Carcinoma.Cancers · 2023Review
- Solid extraintestinal malignancies in patients with inflammatory bowel disease.World journal of gastrointestinal oncology · 2021Review
- 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.Cancer research · 2019Article
- Radiation-induced alternative transcripts as detected in total and polysome-bound mRNA.Oncotarget · 2018Article
- Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells.Cancer research · 2016Article
- Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas.Cancer research · 2016Article
- Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.International journal of molecular sciences · 2015Review
- Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis.Journal of experimental & clinical cancer research : CR · 2015Article
- Cancer-related inflammation.Journal of clinical immunology · 2013Review
- Systemic VHL gene functions and the VHL disease.FEBS letters · 2012Review
- Role of TLR2-dependent inflammation in metastatic progression.Annals of the New York Academy of Sciences · 2011Review
- Tumor necrosis factor receptor expression and signaling in renal cell carcinoma.The American journal of pathology · 2010Article
- The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans.The Journal of clinical investigation · 2009Article
- Tumour necrosis factor and cancer.Nature reviews. Cancer · 2009Review
- C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation.Biomarker insights · 2007Article
- The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells.Cancer research · 2007Article
- Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.Molecular and cellular biology · 2006Article
- Searching for IRES.RNA (New York, N.Y.) · 2006Review
- Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.Molecular and cellular biology · 2006Article
- Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma.British journal of cancer · 2005Article
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Authors and funding
10 authors.
Funding
Abstract
Based on evidence that the von Hippel-Lindau (VHL) tumor suppressor protein is associated with polysomes and interacts with translation regulatory factors, we set out to investigate the potential influence of pVHL on protein translation. To this end, renal cell carcinoma (RCC) cells that either lacked pVHL or expressed pVHL through stable transfection were used to prepare RNA from cytosolic (unbound) and polysome-bound fractions. Hybridization of cDNA arrays using RNA from each fraction revealed a subset of transcripts whose abundance in polysomes decreased when pVHL function was restored. The tumor necrosis factor alpha (TNF-alpha) mRNA was identified as one of the transcripts that preferentially associated with polysomes in pVHL-deficient cells. Additional evidence that the TNF-alpha mRNA was a target of translational repression by pVHL was obtained from reporter gene assays, which further revealed that pVHL's inhibitory influence on protein synthesis occurred through the TNF-alpha 3'-untranslated region. Our findings uncover a novel function for the pVHL tumor suppressor protein as regulator of protein translation.
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