Trial reportJournal of neurology, neurosurgery, and psychiatry2003
Neuromuscular and sensory disturbances in patients with well treated coeliac disease.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review.Nutrients · 2019Pooled it
- Pooled it
- The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome.Journal of veterinary internal medicineTrial
- Celiac Disease and the Nervous System: A Comprehensive Overview of Neurological Manifestations and Underlying Mechanisms.Neuromolecular medicine · 2026Review
- Celiac disease as a model of gut-brain autoimmunity: from gluten exposure to neuropsychiatric manifestations.Frontiers in pediatrics · 2026Review
- Small-fibre neuropathy in coeliac disease: a cross-sectional study.Frontiers in neurology · 2026Article
- Volumetric Analysis of Motor Cortex and Basal Ganglia in Pediatric Celiac Disease Patients Using volBrain: Implications for Neurological Dysfunction-Preliminary Results.Diagnostics (Basel, Switzerland) · 2024Article
- Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?Journal of clinical medicine · 2022Review
- Acrodystrophic axonal polyneuropathy with celiac disease: a case report.Journal of medical case reports · 2021Article
- Review
- Inducible knockout of Clec16a in mice results in sensory neurodegeneration.Scientific reports · 2021Article
- Living with Gluten and Other Food Intolerances: Self-Reported Diagnoses and Management.Nutrients · 2020Article
- Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease.PloS one · 2020Article
- Neuroimmunogastroenterology: At the Interface of Neuroimmunology and Gastroenterology.Frontiers in neurology · 2020Review
- Does celiac disease cause autoimmune sensorineural hearing loss?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Causes of chronic neuropathies: a single-center experience.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Peripheral neuropathy and gastroenterologic disorders: an overview on an underrecognized association.Acta bio-medica : Atenei Parmensis · 2018Review
- Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation aInternational journal of molecular sciences · 2018Review
- Coeliac disease as a potential cause of idiopathic portal hypertension: a case report.Gastroenterology report · 2018Article
- Cortical involvement in celiac disease before and after long-term gluten-free diet: A Transcranial Magnetic Stimulation study.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA body of evidence shows that coeliac disease is associated with protean manifestations outside the intestine, and neurological disorders are well recognised. However, it remains obscure whether there are signs of clinical or subclinical nervous system involvement even in patients adopting an adequate gluten free diet. The aim of this study was to assess in a controlled study whether patients with treated coeliac disease carry an increased risk for neuropathy and characterise the type of possible neuropathy.
methodsElectroneuromyographic findings and vibration, thermal, and tactile thresholds of 26 patients with coeliac disease and 23 patients with reflux disease were analysed.
resultsSix (23.1 %) coeliac disease patients and one (4.3 %) reflux disease patient showed findings of chronic axonal neuropathy in quantitative needle EMG. In addition, two coeliac disease patients showed findings suggestive for myopathy. There were no significant differences in warm, cold, or vibration thresholds between the groups but means of heat pain thresholds and tactile thresholds were significantly higher in coeliac patients than in controls.
conclusionAn increased occurrence of axonal neuropathy was observed in well treated coeliac disease. This further indicates that neurological manifestations occur even in patients without overt malabsorption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.