ArticleThe Journal of physiology2003
Single-axon action potentials in the rat hippocampal cortex.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
- Variations of neuronal properties in the region of locus coeruleus of mice.Brain research · 2024Article
- Spike transmission failures in axons from cortical neuronsiScience · 2024Article
- Transthalamic Pathways for Cortical Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- More than expected: extracellular waveforms and functional responses in monkey LGN.bioRxiv : the preprint server for biology · 2024Article
- Spike transmission failures in axons from mouse cortical pyramidal neurons in vivo.bioRxiv : the preprint server for biology · 2024Article
- Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.Communications biology · 2023Article
- Characterization of extracellular spike waveforms recorded in wallaby primary visual cortex.Frontiers in neuroscience · 2023Review
- Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array.Frontiers in neuroscience · 2022Article
- Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block.IEEE transactions on bio-medical engineering · 2021Article
- Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Intermittent Failure of Spike Propagation in Primary Afferent Neurons during Tactile Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner.Scientific reports · 2019Article
- Fast and flexible sequence induction in spiking neural networks via rapid excitability changes.eLife · 2019Article
- A modular degron library for synthetic circuits in mammalian cells.Nature communications · 2019Article
- The Slow Depolarization Following Individual Spikes in Thin, Unmyelinated Axons in Mammalian Cortex.Frontiers in cellular neuroscience · 2019Article
- Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Methylmercury reduces synaptic transmission and neuronal excitability in rat hippocampal slices.Pflugers Archiv : European journal of physiology · 2018Article
- An Optimized Structure-Function Design Principle Underlies Efficient Signaling Dynamics in Neurons.Scientific reports · 2018Article
- Scaling of Optogenetically Evoked Signaling in a Higher-Order Corticocortical Pathway in the Anesthetized Mouse.Frontiers in systems neuroscience · 2018Article
1 more citing papers are in PubMed but not listed here.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Whether all action potentials propagate faithfully throughout axon arbors in the mammalian CNS has long been debated, and remains an important issue because many synapses occur far from the soma along extremely thin, unmyelinated, varicosity-laden branches of axon arbors. We detected unitary action potentials along individual axon branches of adult hippocampal CA3 pyramidal cells using extracellular electrodes, and analysed their conduction across long distances (mean, 2.1 mm) at 22 and 37 degrees C. Axons nearly always transmitted low-frequency impulses. At higher frequencies, most axons also transmitted impulses with striking fidelity. However, at paired-pulse frequencies in the hundreds of kilohertz range, axons exhibited variability: refractory periods ranged from 2.5 to 10 ms at 37 degrees C and from 5 to 40 ms at 22 degrees C. Although the basis for the refractory period variability could not be determined, these limits overlap with CA3 spike frequencies observed in vivo, raising the possibility that some axonal branches act as filters for the higher-order spikes in bursts, in contrast to the observed first-spike reliability. These results extend the observations of propagation reliability to a much longer distance and higher frequency domain than previously reported, and suggest a high safety factor for action potential propagation along thin, varicose axons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.