ArticleThe Journal of physiology2003
Intraterminal Ca2+ concentration and asynchronous transmitter release at single GABAergic boutons in rat collicular cultures.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Presynaptic maturation of inhibitory connections onto vasoactive intestinal polypeptide-expressing GABAergic interneurons in the mouse barrel field.Pflugers Archiv : European journal of physiology · 2025Article
- The Parvalbumin Hypothesis of Autism Spectrum Disorder.Frontiers in cellular neuroscience · 2020Article
- Different patterns of neuronal activity trigger distinct responses of oligodendrocyte precursor cells in the corpus callosum.PLoS biology · 2017Article
- Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Pharmacological reviews · 2017Review
- Short-term potentiation of GABAergic synaptic inputs to vasopressin and oxytocin neurones.The Journal of physiology · 2014Article
- An alien divalent ion reveals a major role for Ca²⁺ buffering in controlling slow transmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release.PloS one · 2014Article
- Slow changes in Ca2(+) cause prolonged release from GABAergic retinal amacrine cells.Journal of neurophysiology · 2013Article
- Synaptic scaling stabilizes persistent activity driven by asynchronous neurotransmitter release.Neural computation · 2011Article
- Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins.Frontiers in cellular neuroscience · 2011Article
- Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.PLoS biology · 2010Article
- Impaired GABAergic inhibition in the visual cortex of brain-derived neurotrophic factor heterozygous knockout mice.The Journal of physiology · 2008Article
- Cajal Retzius cells in the mouse neocortex receive two types of pre- and postsynaptically distinct GABAergic inputs.The Journal of physiology · 2007Article
- Kinetics of both synchronous and asynchronous quantal release during trains of action potential-evoked EPSCs at the rat calyx of Held.The Journal of physiology · 2007Article
- Adaptation reduces spike-count reliability, but not spike-timing precision, of auditory nerve responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ambient GABA constrains the strength of GABAergic synapses at Cajal-Retzius cells in the developing visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- beta-Adrenoceptor-mediated long-term up-regulation of the release machinery at rat cerebellar GABAergic synapses.The Journal of physiology · 2005Article
- Time-matched pre- and postsynaptic changes of GABAergic synaptic transmission in the developing mouse superior colliculus.The Journal of physiology · 2005Article
- Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotransmitter release in response to a single action potential has a precise time course. A significant fraction of the releasable vesicles is exocytosed synchronously, within a few milliseconds after the arrival of an action potential. If repeatedly activated, stimulus-locked phasic synchronous release declines, but synaptic transmission can be maintained through tonic asynchronous transmitter release. The desynchronisation of release during repetitive activation is generally attributed to a build-up of intraterminal Ca2+ concentration. However, the precise relationship between presynaptic Ca2+ level and asynchronous release rate at small central synapses has remained unclear. Here we characterise this relationship for single GABAergic terminals in rat collicular cultures. In the presence of tetrodotoxin, inhibitory postsynaptic currents (IPSCs) and presynaptic Ca2+ transients were recorded in response to direct presynaptic depolarisation of individual boutons. Repetitive stimulation indeed resulted in a shift from phasic to asynchronous neurotransmitter release. A clear dominance of the asynchronous release mode was observed after 10 pulses. The steady-state asynchronous release rate showed a third-power dependency on the presynaptic Ca2+ concentration, which is similar to that of evoked release. The Ca2+ sensor for asynchronous release exhibited a high affinity for Ca2+ and was far from saturation. These properties of the Ca2+ sensor should make the asynchronous release very sensitive to any modification of presynaptic Ca2+ concentration, including those resulting from changes in presynaptic activity patterns. Thus, asynchronous release represents a powerful but delicately regulated mechanism that ensures the maintenance of appropriate inhibition when the readily releasable pool of vesicles is depleted.
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