ArticleThe Journal of physiology2003
Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neurons.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 1: Modulation of TRPM4.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 2: TRPM4 in Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ.Scientific reports · 2017Article
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- Intracellular chloride concentration of the mouse vomeronasal neuron.BMC neuroscience · 2015Article
- A TRPM4-dependent current in murine renal primary cilia.American journal of physiology. Renal physiology · 2015Article
- Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.The Journal of general physiology · 2015Article
- TRICK or TRP? What Trpc2(-/-) mice tell us about vomeronasal organ mediated innate behaviors.Frontiers in neuroscience · 2015Article
- Article
- Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C δ (PKCδ) and stromal interaction molecule 2 (STIM2).The Journal of biological chemistry · 2012Article
- Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.Nature neuroscience · 2012Article
- Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons.The Journal of general physiology · 2012Article
- G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons.Nature communications · 2011Article
- Odors activate dual pathways, a TRPC2 and a AA-dependent pathway, in mouse vomeronasal neurons.American journal of physiology. Cell physiology · 2010Article
- Calcium-activated chloride current amplifies the response to urine in mouse vomeronasal sensory neurons.The Journal of general physiology · 2010Article
- Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Urine stimulation activates BK channels in mouse vomeronasal neurons.Journal of neurophysiology · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Bipolar sensory neurons within the vomeronasal organ (VNO) are thought to mediate the detection of pheromones in vertebrates. In the mouse, VNO neurons respond to pheromones with a rise in intracellular Ca2+ that accompanies a depolarization of the cell. Transduction of the pheromone appears to occur through the activation of a phosphatidylinositol signalling pathway, but the ion channels that respond to this signalling pathway have not been identified. In this report patch-clamp recording from hamster vomeronasal sensory neurons was used to identify second-messenger-gated channels that might play a role in transduction. The results demonstrate that VNO neurons show abundant expression of a Ca2+-activated non-selective (CaNS) cation channel. The CaNS channel does not discriminate between Na+ and K+ and has a slope conductance of 22 pS. Half-activation of the channel occurs at a Ca2+ concentration of 0.5 mM (at -80 mV). The probability of opening (Po) of the channel is further augmented at positive potentials, and shows an e-fold voltage dependence per 37 mV. The channel exhibits rapid rundown following patch excision with Po decreasing from near 1.0 to near 0. The adenine nucleotides ATP and cAMP block the channel with an apparent affinity of 3 and 42 microM, respectively (-80 mV). Both the activation of the channel by Ca2+ and the block of the channel by adenine nucleotides show a mild voltage dependence, which can be accounted for by the voltage dependence of Po. The properties of this channel make it a candidate to either directly mediate vomeronasal sensory transduction, or to amplify the primary sensory response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.