ArticleThe Journal of clinical investigation2003
Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- A Case Report of Secondary Syphilis Co-Infected with Measles: A Diagnostic Dilemma with Fever and Rash.Tropical medicine and infectious disease · 2022Article
- Current State and Promising Opportunities on Pharmaceutical Approaches in the Treatment of Polymicrobial Diseases.Pathogens (Basel, Switzerland) · 2021Review
- Missed vaccinations and critical care admission: all you may wish to know or rediscover-a narrative review.Intensive care medicine · 2020Review
- Microbiome shifts with onset and progression of Sea Star Wasting Disease revealed through time course sampling.Scientific reports · 2018Article
- Review
- The epidemiological and serological characteristics of measles in Dongguan, China, 2005-2014.Human vaccines & immunotherapeutics · 2016Article
- Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Cell host & microbe · 2016Article
- Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats.Veterinary microbiology · 2014Article
- The epidemiological and clinical characteristics of measles in Wenzhou, China, 2000-2010.Epidemiology and infection · 2014Article
- Measles virus C protein interferes with Beta interferon transcription in the nucleus.Journal of virology · 2012Article
- Article
- Simian virus 40 inhibits differentiation and maturation of rhesus macaque DC-SIGN(+) dendritic cells.European journal of medical research · 2010Article
- The role of phagocytic cells in enhanced susceptibility of broilers to colibacillosis after Infectious Bronchitis Virus infection.Veterinary immunology and immunopathology · 2008Article
- Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response.Journal of virology · 2006Article
- Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS).Microbes and infection · 2006Article
- Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination.Journal of virology · 2005Article
- Tropism illuminated: lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Developing animal models for polymicrobial diseases.Nature reviews. Microbiology · 2004Review
- Measles virus interacts with human SLAM receptor on dendritic cells to cause immunosuppression.Virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Among infectious agents, measles virus (MV) remains a scourge responsible for 1 million deaths per year and is a leading cause of childhood deaths in developing countries. Although MV infection itself is not commonly lethal, MV-induced suppression of the immune system results in a greatly increased susceptibility to opportunistic bacterial infections that are largely responsible for the morbidity and mortality associated with this disease. Despite its clinical importance, the underlying mechanisms of MV-induced immunosuppression remain unresolved. To begin to understand the basis of increased susceptibility to bacterial infections during MV infection, we inoculated transgenic mice expressing the MV receptor, CD46, with MV and Listeria monocytogenes. We found that MV-infected mice were more susceptible to infection with Listeria and that this corresponded with significantly decreased numbers of macrophages and neutrophils in the spleen and substantial defects in IFN-gamma production by CD4(+) T cells. The reduction in CD11b(+) macrophages and IFN-gamma-producing T cells was due to reduced proliferative expansion and not to enhanced apoptosis or to altered distribution of these cells between spleen, blood, and the lymphatic system. These results document that MV infection can suppress both innate and adaptive immune responses and lead to increased susceptibility to bacterial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.