ArticleAmerican journal of human genetics2003
Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 96 citations in OpenAlex.
- Genetics of Familial Combined Hyperlipidemia (FCHL) Disorder: An Update.Biochemical genetics · 2022Review
- Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.Human genomics · 2021Article
- Atherosclerosis and transit of HDL through the lymphatic vasculature.Current atherosclerosis reports · 2013Review
- Linkage of type 2 diabetes on chromosome 9p24 in Mexican Americans: additional evidence from the Veterans Administration Genetic Epidemiology Study (VAGES).Human heredity · 2013Article
- Exome sequencing identifies 2 rare variants for low high-density lipoprotein cholesterol in an extended family.Circulation. Cardiovascular genetics · 2012Article
- The role of large pedigrees in an era of high-throughput sequencing.Human genetics · 2012Review
- Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.Journal of lipid research · 2011Article
- The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol.Journal of lipid research · 2011Article
- Unifying ideas for non-parametric linkage analysis.Human heredity · 2011Article
- WWOX gene is associated with HDL cholesterol and triglyceride levels.BMC medical genetics · 2010Article
- Genetic causes of high and low serum HDL-cholesterol.Journal of lipid research · 2010Review
- A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI.Journal of lipid research · 2010Article
- Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease.European journal of human genetics : EJHG · 2010Article
- Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.European journal of human genetics : EJHG · 2010Article
- Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels.Circulation. Cardiovascular genetics · 2009Article
- WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.American journal of human genetics · 2008Article
- FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis.BMC bioinformatics · 2008Article
- A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors.Atherosclerosis · 2008Article
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
Several genomewide screens have been performed to identify novel loci predisposing to unfavorable serum lipid levels and coronary heart disease (CHD). We hypothesized that the accumulating data of these screens in different study populations could be combined to verify which of the identified loci truly harbor susceptibility genes. The power of this strategy has recently been demonstrated with other complex diseases, such as inflammatory bowel disease and asthma. We assessed the largely unknown genetic background of CHD by investigating the most common dyslipidemia predisposing to CHD, familial combined hyperlipidemia (FCHL), affecting 1%-2% of Western populations and 10%-20% of families with premature CHD. To be able to perform a combined data analysis, we unified the diagnostic criteria for FCHL and its component traits and combined the data from two genomewide scans performed in two populations, the Finns and the Dutch. As a result of our pooled data analysis, we identified three chromosomal regions, on chromosomes 2p25.1, 9p23, and 16q24.1, exceeding the statistical significance level of a LOD score >2.0. The 2p25.1 region was detected for the FCHL trait, and the 9p23 and 16q24.1 regions were detected for the low high-density lipoprotein cholesterol (HDL-C) trait. In addition, the previously recognized 1q21 region also obtained additional support in the other study sample, when the triglyceride trait was used. Analysis of the 16q24.1 region resulted in a statistically significant LOD score of 3.6 when the data from Finnish families with low HDL-C were included in the analysis. To search for the underlying gene in the 16q24.1 region, we investigated a novel functional and positional candidate gene, helix/forkhead transcription factor (FOXC2), by sequencing and by genotyping of two single-nucleotide polymorphisms in the families.
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