Evidence map›Paper›PMID 12637766›Full record

ReviewImmunologic research2003

Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

T Kevin Howcroft, Dinah S Singer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

T Kevin HowcroftExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1360, USA. HowcrofK@Exchange.nih.gov
Dinah S Singer
National Cancer Institute · USNational Institutes of Health · US

Funding

Regulation of Expression of MHC Class I GenesZIABC009279 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, DINAH S. · 2009 to 2018
$4.3M
REGULATION OF EXPRESSION OF MHC CLASS I GENESZ01BC009279 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, DINAH S. · 1996 to 2008
$1.3M
6 · The paper itself

Abstract

Peptide binding proteins of the major histocompatibility complex consist of the "classical" class Ia and "nonclassical" class Ib genes. The gene organization and structure/function relationship of the various exons comprising class I proteins are very similar among the class Ia and class Ib genes. Although the tissue-specific patterns of expression of these two gene families are overlapping, many class Ib genes are distinguished by relative low abundance and/or limited tissue distribution. Further, many of the class Ib genes serve specialized roles in immune responses. Given that the coding sequences of the class Ia and class Ib genes are highly homologous we sought to examine the promoter regions of the various class Ib genes by comparison to the well characterized promoter elements regulating expression of the class Ia genes. This analysis revealed a surprising complexity of promoter structures among all class I genes and few instances of conservation of class Ia promoter regulatory elements among the class Ib genes.

Indexed as

AnimalsBase SequenceConserved SequenceGene Expression RegulationGenes, MHC Class IHumansMiceMolecular Sequence DataRegulatory Sequences, Nucleic AcidSelection, GeneticSequence Alignment

Identifiers

PMID12637766
OpenAlexW2326452144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.