ArticleThe Journal of biological chemistry2003
Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis.
Article in The Journal of biological chemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 70 citations in OpenAlex.
- Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.The Journal of biological chemistry · 2024Article
- Let's make it clear: systematic exploration of mitochondrial DNA- and RNA-protein complexes by complexome profiling.Nucleic acids research · 2023Article
- Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension.Frontiers in cell and developmental biology · 2021Article
- Mam33 promotes cytochrome c oxidase subunit I translation in Saccharomyces cerevisiae mitochondria.Molecular biology of the cell · 2015Article
- The thumb subdomain of yeast mitochondrial RNA polymerase is involved in processivity, transcript fidelity and mitochondrial transcription factor binding.RNA biology · 2015Article
- Mitochondrial Transcription Factor A (TFAM) Binds to RNA Containing 4-Way Junctions and Mitochondrial tRNA.PloS one · 2015Article
- Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.Nucleic acids research · 2013Article
- Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome.Nucleic acids research · 2013Article
- Article
- Mitochondrial protein synthesis, import, and assembly.Genetics · 2012Article
- Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mitochondrial DNA transcription regulation and nucleoid organization.Journal of inherited metabolic disease · 2011Review
- Mitochondrial DNA mutations in disease and aging.The Journal of cell biology · 2011Review
- The N-terminal domain of the yeast mitochondrial RNA polymerase regulates multiple steps of transcription.The Journal of biological chemistry · 2011Article
- TEFM (c17orf42) is necessary for transcription of human mtDNA.Nucleic acids research · 2011Article
- Article
- A compendium of human mitochondrial gene expression machinery with links to disease.Environmental and molecular mutagenesis · 2010Review
- Yeast AEP3p is an accessory factor in initiation of mitochondrial translation.The Journal of biological chemistry · 2009Article
- Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification.Yeast (Chichester, England) · 2009Article
- Mitochondrial fatty acid synthesis type II: more than just fatty acids.The Journal of biological chemistry · 2009Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
The amino-terminal domain (ATD) of Saccharomyces cerevisiae mitochondrial RNA polymerase has been shown to provide a functional link between transcription and post-transcriptional events during mitochondrial gene expression. This connection is mediated in large part by its interactions with the matrix protein Nam1p and, based on genetic phenotypes, the mitochondrial membrane protein Sls1p. These observations led us to propose previously that mtRNA polymerase, Nam1p, and Sls1p work together to coordinate transcription and translation of mtDNA-encoded gene products. Here we demonstrate by specific labeling of mitochondrial gene products in vivo that Nam1p and Sls1p indeed work together in a pathway that is required globally for efficient mitochondrial translation. Likewise, mutations in the ATD result in similar global reductions in mitochondrial translation efficiency and sensitivity to the mitochondrial translation inhibitor erythromycin. These data, coupled with the observation that the ATD is required to co-purify Sls1p in association with mtDNA nucleoids, suggest that efficient expression of mtDNA-encoded genes in yeast involves a complex series of interactions that localize active transcription complexes to the inner membrane in order to coordinate translation with transcription.
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