ArticleAJNR. American journal of neuroradiology2003
Correlations of hippocampal atrophy and focal low-frequency magnetic activity in Alzheimer disease: volumetric MR imaging-magnetoencephalographic study.
Article in AJNR. American journal of neuroradiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 130 citations in OpenAlex.
- Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states.Neural plasticity · 2015Trial
- Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy?European journal of nuclear medicine and molecular imaging · 2005Trial
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- Resting-state EEG biomarkers of general and domain-specific cognitive impairment and plasma P-tau217 in patients with Alzheimer's disease and mild cognitive impairment.Frontiers in neurology · 2026Article
- Amyloid-β deposition predicts oscillatory slowing of magnetoencephalography signals and a reduction of functional connectivity over time in cognitively unimpaired adults.Brain communications · 2025Article
- Article
- Oscillatory characteristics of resting-state magnetoencephalography reflect pathological and symptomatic conditions of cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes.bioRxiv : the preprint server for biology · 2023Article
- Mild Cognitive Impairment in African Americans Is Associated with Differences in EEG Theta/Beta Ratio.Journal of Alzheimer's disease : JAD · 2023Article
- The effect of EEG and fNIRS in the digital assessment and digital therapy of Alzheimer's disease: a systematic review.Frontiers in neuroscience · 2023Review
- The Aging Patterns of Brain Structure, Function, and Energy Metabolism.Advances in experimental medicine and biology · 2023Article
- EEG asymmetry and cognitive testing in MCI identification.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Distinctive effects of executive dysfunction and loss of learning/memory abilities on resting-state brain activity.Scientific reports · 2022Article
- Who's driving? The default mode network in healthy elderly individuals at risk of cognitive decline.Frontiers in neurology · 2022Article
- Novelty detection-based approach for Alzheimer's disease and mild cognitive impairment diagnosis from EEG.Medical & biological engineering & computing · 2021Article
- Observational
- Permutation Entropy and Statistical Complexity in Mild Cognitive Impairment and Alzheimer's Disease: An Analysis Based on Frequency Bands.Entropy (Basel, Switzerland) · 2020Article
- EEG spectral power abnormalities and their relationship with cognitive dysfunction in patients with Alzheimer's disease and type 2 diabetes.Neurobiology of aging · 2020Article
- Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease.Brain : a journal of neurology · 2018Article
- Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.Journal of Alzheimer's disease : JAD · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatients with Alzheimer disease (AD) have more low-frequency activity on conventional EEG and increased focal magnetoencephalographic (MEG) dipole density (DD) in delta and theta bands. This activity concurs with atrophy and reduced metabolic and perfusion rates, particularly in temporoparietal structures. The relationship between functional and structural measures and their conjoined capability to improve the diagnosis of AD were assessed in this study.
methodsWhole-head MEG recordings were obtained in 15 patients in whom the diagnosis of AD had been made and in 16 healthy control subjects during a resting condition. MR imaging volumetric data were also obtained; these included global cerebral, temporal lobe, and hippocampal volumes.
resultsDD in the delta and theta bands was enhanced in the AD group compared with the healthy control subjects. Slow-wave activity differed significantly between the groups in the temporoparietal regions of both hemispheres. Left hippocampal volume was correlated with left temporal and parietal delta DD and left temporal theta DD. A combination of left hippocampal volume and left temporal theta DD enabled correct classification in 87.1% of the patients with AD or control subjects.
conclusionResults support the predominant role of temporoparietal hypofunction as defined by DD and hippocampal structural deficits shown on MR images in patients with AD. A multidisciplinary perspective of different techniques may improve our understanding of the disease and our diagnostic abilities.
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12637301PMC7973601W2122911185What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.