ArticleJournal of neuro-oncology2002
New approach to tumor therapy for inoperable areas of the brain: chronic intraparenchymal drug delivery.
Article in Journal of neuro-oncology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Unlocking Dendrimers Future Potential for Brain-Specific Drug Delivery in Cerebroanoreach.Recent advances in drug delivery and formulation · 2025Review
- Gas Plasma Exposure of Glioblastoma Is Cytotoxic and Immunomodulatory in Patient-Derived GBM Tissue.Cancers · 2022Article
- Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs.European journal of medicinal chemistry · 2021Review
- Radiation therapy combined with intracerebral convection-enhanced delivery of cisplatin or carboplatin for treatment of the F98 rat glioma.Journal of neuro-oncology · 2020Review
- Dendrimer-Based Drug Delivery Systems for Brain Targeting.Biomolecules · 2019Review
- Convection-enhanced drug delivery for gliomas.Surgical neurology international · 2015Article
- Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Article
- Intracerebral delivery of carboplatin in combination with either 6 MV photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.Journal of experimental & clinical cancer research : CR · 2012Article
- The effects of temozolomide delivered by prolonged intracerebral microinfusion against the rat brainstem GBM allograft model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.Journal of neuro-oncology · 2011Article
- Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates.NeuroImage · 2011Article
- A human brainstem glioma xenograft model enabled for bioluminescence imaging.Journal of neuro-oncology · 2010Article
- Interstitial continuous infusion therapy in a malignant glioma model in rats.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Enhanced survival and cure of F98 glioma-bearing rats following intracerebral delivery of carboplatin in combination with photon irradiation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2007Article
- Brain Stem Tumors.Current treatment options in neurology · 2005Article
- Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine.Journal of neuro-oncology · 2004Article
- Toxicity and cerebrospinal fluid levels of carboplatin chronically infused into the brainstem of a primate.Journal of neuro-oncology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because the brainstem has little functional redundancy, diffuse lesions have been regarded as inoperable. To determine whether local drug therapy can prolong survival in a rodent model of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were injected into the brainstems of Fischer 344 rats. Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at 1 microl/h for 7 days. Compared to control groups that survived 13-17 days with F98 tumors and 22-23 days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived 27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01), respectively. Measurements of tissue platinum levels at autopsy suggested that infusions distributed pharmacologically relevant levels of carboplatin through a volume of tissue at least 0.5 cm in diameter. The results suggest that chronic low-flow infusions provide a promising approach to therapy for CNS lesions in tissues considered to be inoperable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.