ArticleJournal of neuro-oncology2002
CD44H is expressed by cells of the oligodendrocyte lineage and by oligodendrogliomas in humans.
Article in Journal of neuro-oncology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Expression of CD44 and Its Spliced Variants: Innate and Inducible Roles in Nervous Tissue Cells and Their Environment.International journal of molecular sciences · 2025Review
- From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis.Brain sciences · 2023Review
- CD44: molecular interactions, signaling and functions in the nervous system.Frontiers in cellular neuroscience · 2015Review
- Myelin architecture: zippering membranes tightly together.Cellular and molecular life sciences : CMLS · 2014Review
- Glial progenitors as targets for transformation in glioma.Advances in cancer research · 2014Review
- Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dynamic changes of CD44 expression from progenitors to subpopulations of astrocytes and neurons in developing cerebellum.PloS one · 2013Article
- Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.Journal of child neurology · 2008Review
- Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitors.Journal of child neurology · 2008Article
- Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas.Virchows Archiv : an international journal of pathology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD44, a family of cell surface glycoproteins involved in cell-cell and cell-extracellular matrix adhesion, is widely expressed in the white matter of the normal brain and in astrocytic gliomas under its standard form (CD44s also called CD44H). On the other hand, several variants have been found in brain metastases and rarely found in gliomas. We have investigated by immunohistochemistry CD44H and CD44v6 expression in 28 oligodendrogliomas. All tumors were CD44v6 negative whereas nearly all tumors were immunolabelled with anti-CD44H antibody. Immunostaining increased in parallel with grade and was particulary strong around vessels and in tumoral subpial nodules. Western blot analysis showed that oligodendrogliomas expressed the same 80-kDa CD44 isoform as normal brain. Since gliomas may arise from a dividing progenitor cell, we also studied CD44H expression during the oligodendrocyte lineage in vitro in parallel with specific markers of the O-2A cells. Precursor cells (PSA-NCAM positive), O-2A progenitor cells, as well as preoligodendrocytes (A2B5 positive cells) and immature oligodendrocytes (O4 positive cells), coexpressed CD44H. Our data showed that CD44H is expressed by cells of the oligodendrocyte lineage in vitro and by oligodendrogliomas in vivo especially in sites of dissemination such as subpial spaces. This suggests that CD44H could play a role in migration of tumor cells in oligodendrocytic tumors.
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