ArticleEuropean journal of clinical pharmacology2003
Potential drug-drug interactions in the medication of medical patients at hospital discharge.
Article in European journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 193 citations in OpenAlex.
- Patterns of drug prescription in a geriatric evaluation and management unit as compared with the general medical wards: a randomised study.European journal of clinical pharmacology · 2005Trial
- Assessment of Potential Drug-Drug Interactions and Associated Factors Among Pulmonary Inpatients in a Tertiary Care Hospital: A Cross-Sectional Study.Drugs - real world outcomes · 2026Article
- Potential drug-drug interactions in hospitalized patients with acute coronary syndrome at a tertiary care hospital in upper Egypt.Frontiers in pharmacology · 2026Article
- Burden and Determinants of Drug-Drug Interactions at Hospital Discharge: Warfarin as a Model for High-Risk Medication Safety.Clinics and practice · 2025Article
- Potential drug-drug interactions among geriatric oncology patients: a retrospective study in Saudi Arabia.BMC geriatrics · 2025Article
- Facilitators and Barriers to Uptake of Drug-Drug Interaction Alerts: Perspectives of Australian End Users and Managers.Applied clinical informatics · 2025Article
- Exploring potential drug-drug interactions in discharge prescriptions: ChatGPT's effectiveness in assessing those interactions.Exploratory research in clinical and social pharmacy · 2025Article
- A Data Mining Approach on Polypharmacy and Drug-drug Interactions of Common Diabetes Medications.Current drug metabolism · 2025Review
- Polypharmacy and high-alert medications in patients with nasally placed feeding tube on admission and at hospital discharge: Multicenter cross-sectional study.Exploratory research in clinical and social pharmacy · 2024Article
- Predictors of potential clinically harmful drug-drug interactions at the medical wards in the University of Benin Teaching Hospital, Benin City.Clinical and translational science · 2024Article
- Barriers to Adoption of Tailored Drug-Drug Interaction Clinical Decision Support.Applied clinical informatics · 2023Article
- The Prevalence and Severity of Potential Drug-Drug Interactions in Internal Medicine Ward at Soba Teaching Hospital.Drug, healthcare and patient safety · 2023Article
- Similarity and consistency assessment of three major online drug-drug interaction resources.British journal of clinical pharmacology · 2022Article
- Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes.Pharmacoepidemiology and drug safety · 2022Article
- Potential Drug-drug Interactions among Hospital Discharge Prescriptions in a Tertiary Care Centre of Nepal: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2022Article
- Potential Drug-Drug Interactions in Hospitalized Medical Patients: Data From Low Resource Settings.Cureus · 2021Article
- Does DDI-Predictor Help Pharmacists to Detect Drug-Drug Interactions and Resolve Medication Issues More Effectively?Metabolites · 2021Article
- Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda.BMC infectious diseases · 2020Article
- Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?BMC pharmacology & toxicology · 2019Article
- Studying the Prevalence of Medical Interventions in the Recipes.Open access Macedonian journal of medical sciences · 2019Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInformation on the frequency of drug combinations with the potential to induce dangerous drug-drug interactions (DDIs) in patients discharged from the hospital is scarce. With the present study, we assessed the frequency and potential clinical significance of DDIs in the prescriptions of discharged medical patients.
methodsWe retrospectively screened the medication for potential DDIs of 500 patients consecutively discharged with at least two prescriptions using a computerised drug-interaction program.
resultsThe 500 patients (56.6% male, mean age 67.0+/-15.9 years, median length of stay 13 days) were prescribed a median of six drugs (range 2-18) at discharge. Three hundred patients (60.0%; 95% confidence interval 55.7-64.3%) had at least one potentially interacting drug combination. Of 747 potential DDIs at discharge overall, 402 (53.8%) were new at the time of discharge due to a change of the medication during the hospital stay. Of these, 72 (17.9%) were of potentially minor, 281 (69.9%) of moderate and 49 (12.2%) of major severity. Of 44 patients with a potential DDI with major severity, 1 patient was re-hospitalised within 2 months after discharge due to a probable drug-related problem associated with the potential DDI.
conclusionsUsing a computerised drug-interaction program, a high proportion of patients was detected with at least one potential DDI in the medication prescribed at discharge. However, the proportion of DDIs associated with potentially relevant clinical consequences appeared to be relatively low.
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