ReviewRheumatology international2003
Pathologic thrombopoiesis of rheumatoid arthritis.
Review in Rheumatology international, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Mean platelet volume, red cell distribution width, platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios in patients with ankylosing spondylitis and their relationships with high-frequency hearing thresholds.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Trial
- Article
- Identifying antinuclear antibody positive individuals at risk for developing systemic autoimmune disease: development and validation of a real-time risk model.Frontiers in immunology · 2024Article
- Mean Platelet Volume in a Series of 315 Patients with Rheumatoid Arthritis: Relationship with Disease Characteristics, including Subclinical Atherosclerosis and Cardiovascular Comorbidity.Diagnostics (Basel, Switzerland) · 2023Article
- Clinical prediction rule for bacterial arthritis: Chi-squared automatic interaction detector decision tree analysis model.SAGE open medicine · 2023Article
- Is It Possible to Predict Clonal Thrombocytosis in Triple-Negative Patients with Isolated Thrombocytosis Based Only on Clinical or Blood Findings?Journal of clinical medicine · 2021Article
- A Study on Association between Common Haematological Parameters and Disease Activity in Rheumatoid Arthritis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Changes of Platelet Indices in Juvenile Idiopathic Arthritis in Acute Phase and After Two Months Treatment.Iranian journal of pediatrics · 2016Article
- Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis.Clinical ophthalmology (Auckland, N.Z.) · 2015Article
- Thrombocytosis as a prognostic marker in gastrointestinal cancers.World journal of gastrointestinal oncology · 2014Review
- Early growth response-1 (EGR-1) and nuclear factor of activated T cells (NFAT) cooperate to mediate CD40L expression in megakaryocytes and platelets.The Journal of biological chemistry · 2013Article
- Scanning electron microscopy of fibrin networks in rheumatoid arthritis: a qualitative analysis.Rheumatology international · 2012Article
- Thrombocytosis in rheumatoid arthritis: JAK2V617F-positive essential thrombocythemia.Rheumatology international · 2012Article
- Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications.Rheumatology international · 2011Review
- Thrombocytosis: diagnostic evaluation, thrombotic risk stratification, and risk-based management strategies.Thrombosis · 2011Article
- Differing effect of systemic anti psoriasis therapies on platelet physiology--a case report and review of literature.BMC dermatology · 2010Review
- Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential thrombocythemia.Cancer research · 2009Article
- Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome.Journal of biomolecular techniques : JBT · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is frequently complicated by thrombocytosis correlated with disease activity. The exact pathogenetic mechanism(s) that cause increased platelet counts in RA are still unknown. Recent investigations indicate that proinflammatory pleiotropic cytokines of RA also have megakaryocytopoietic/thrombopoietic properties. Moreover, several lineage-dominant hematopoietic cytokines can also act as acute phase responders and contribute to the inflammation. This review focuses on the current literature and our experience regarding the dual relationships of the pathologic thrombopoiesis of RA. Growth factors contributing to it, namely interleukin (IL)-6, IL-11, stem cell factor, leukemia inhibitory factor, granulocyte colony stimulating factor, thrombopoietin (TPO), and the regulation of megakaryocytopoiesis during the inflammatory cascade are reviewed. Some data indicate that thrombopoietin could contribute to the reactive thrombocytosis of RA. In the non-lineage-specific gp130 cytokine family, IL-6 appears to predominate for the induction of megakaryopoiesis. However, other cytokines and growth factors may also contribute to the pathologic megakaryocytopoiesis of RA. Those pleiotropic mediators seem to act in concert to regulate this enigmatic process. Clarification of the pathobiologic basis of thrombopoiesis in RA may improve understanding of the disease pathogenesis and management of the inflammatory thrombocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.