ArticleEMBO reports2003
Bidirectional DNA unwinding by a ternary complex of T antigen, nucleolin and topoisomerase I.
Article in EMBO reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence.Retrovirology · 2023Review
- Chromatin Architectural Factors as Safeguards against Excessive Supercoiling during DNA Replication.International journal of molecular sciences · 2020Review
- The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells.Scientific reports · 2018Article
- Roles of eukaryotic topoisomerases in transcription, replication and genomic stability.Nature reviews. Molecular cell biology · 2016Review
- AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin.PloS one · 2016Article
- IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.PloS one · 2015Article
- Article
- RNA-binding protein nucleolin in disease.RNA biology · 2012Review
- Nucleolin: The most abundant multifunctional phosphoprotein of nucleolus.Communicative & integrative biology · 2011Article
- Nucleolin is required for efficient nuclear egress of herpes simplex virus type 1 nucleocapsids.Journal of virology · 2010Article
- Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.Journal of virology · 2010Article
- Simian virus 40 large T antigen can specifically unwind the central palindrome at the origin of DNA replication.Journal of virology · 2009Article
- Contribution of the individual subunits of protein kinase CK2 and of hPrp3p to the splicing process.Molecular and cellular biochemistry · 2008Article
- Development of an immortalised, post-pubertal gonadotrophin-releasing hormone neuronal cell line.Journal of neuroendocrinology · 2008Article
- Nucleolin is required for an efficient herpes simplex virus type 1 infection.Journal of virology · 2008Article
- Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication.The Biochemical journal · 2007Article
- Role of the hydrophilic channels of simian virus 40 T-antigen helicase in DNA replication.Journal of virology · 2007Article
- Ddx42p--a human DEAD box protein with RNA chaperone activities.Nucleic acids research · 2006Article
- Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.Oncogene · 2005Article
- Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The simian virus 40 large tumour-antigen (T antigen) DNA helicase is a hexameric structure; it has been proposed that, in viral DNA replication, two of these hexamers are combined to form a bipartite holoenzyme that acts concurrently at both forks of a replication bubble. In a search for structural components of this helicase complex, we have identified nucleolin as a specific binding protein for the T-antigen hexamer. We show that nucleolin, in co-operation with human topoisomerase I, mediates the cohesion of the T-antigen helicase holoenzyme during plasmid unwinding. Our results provide biochemical evidence for a direct role of nucleolin in DNA replication, in addition to its known function in ribosome biogenesis. The data presented here suggest that nucleolin enables the formation of a functional 'helicase-swivelase' complex at the replication fork.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.