ArticleJournal of virology2003
In silico pattern-based analysis of the human cytomegalovirus genome.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- The functions of herpesvirus shuttling proteins in the virus lifecycle.Frontiers in microbiology · 2025Review
- Multiple functions of the herpesvirus UL14 gene product in viral infection.Frontiers in microbiology · 2024Review
- Identification and characterization of human cytomegalovirus-encoded circular RNAs.Frontiers in cellular and infection microbiology · 2022Article
- Virus-host interaction analysis in colorectal cancer identifies core virus network signature and small molecules.Computational and structural biotechnology journal · 2022Article
- Immune Correlates of Protection Against Human Cytomegalovirus Acquisition, Replication, and Disease.The Journal of infectious diseases · 2020Article
- Restriction of Human Cytomegalovirus Infection by Galectin-9.Journal of virology · 2019Article
- The DNA damage response induced by infection with human cytomegalovirus and other viruses.Viruses · 2014Review
- Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope.Journal of virology · 2013Article
- Complete genome sequences of elephant endotheliotropic herpesviruses 1A and 1B determined directly from fatal cases.Journal of virology · 2013Article
- The US16 gene of human cytomegalovirus is required for efficient viral infection of endothelial and epithelial cells.Journal of virology · 2012Article
- Human cytomegalovirus entry into cells.Current opinion in virology · 2012Review
- Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.Cell host & microbe · 2008Article
- Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.The American journal of pathology · 2008Article
- The essential human cytomegalovirus gene UL52 is required for cleavage-packaging of the viral genome.Journal of virology · 2008Article
- Desensitization of herpesvirus-encoded G protein-coupled receptors.Life sciences · 2008Review
- Functional analysis of human cytomegalovirus pUS28 mutants in infected cells.The Journal of general virology · 2008Article
- Analysis of the variability of CMV strains in the RL11D domain of the RL11 multigene family.Virus genes · 2007Article
- G protein-coupled receptor (GPCR) kinase 2 regulates agonist-independent Gq/11 signaling from the mouse cytomegalovirus GPCR M33.The Journal of biological chemistry · 2006Article
- Double-stranded RNA binding by a heterodimeric complex of murine cytomegalovirus m142 and m143 proteins.Journal of virology · 2006Article
- Human cytomegalovirus pUS24 is a virion protein that functions very early in the replication cycle.Journal of virology · 2006Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
More than 200 open reading frames (ORFs) from the human cytomegalovirus genome have been reported as potentially coding for proteins. We have used two pattern-based in silico approaches to analyze this set of putative viral genes. With the help of an objective annotation method that is based on the Bio-Dictionary, a comprehensive collection of amino acid patterns that describes the currently known natural sequence space of proteins, we have reannotated all of the previously reported putative genes of the human cytomegalovirus. Also, with the help of MUSCA, a pattern-based multiple sequence alignment algorithm, we have reexamined the original human cytomegalovirus gene family definitions. Our analysis of the genome shows that many of the coded proteins comprise amino acid combinations that are unique to either the human cytomegalovirus or the larger group of herpesviruses. We have confirmed that a surprisingly large portion of the analyzed ORFs encode membrane proteins, and we have discovered a significant number of previously uncharacterized proteins that are predicted to be G-protein-coupled receptor homologues. The analysis also indicates that many of the encoded proteins undergo posttranslational modifications such as hydroxylation, phosphorylation, and glycosylation. ORFs encoding proteins with similar functional behavior appear in neighboring regions of the human cytomegalovirus genome. All of the results of the present study can be found and interactively explored online (http://cbcsrv.watson.ibm.com/virus/).
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