ArticleAnnals of the rheumatic diseases2003
Beneficial effects of the anti-oestrogen tamoxifen on systemic lupus erythematosus of (NZBxNZW)F1 female mice are associated with specific reduction of IgG3 autoantibodies.
Article in Annals of the rheumatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Sex hormones affect the pathogenesis and clinical characteristics of systemic lupus erythematosus.Frontiers in medicine · 2022Pooled it
- Effects of tamoxifen on the immune response phenotype in equine peripheral blood mononuclear cells.Frontiers in veterinary science · 2024Article
- B cell-intrinsic Myd88 regulates disease progression in murine lupus.The Journal of experimental medicine · 2023Article
- Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Lupus and recurrent pregnancy loss: the role of female sex hormones and B cells.Frontiers in endocrinology · 2023Review
- Sex bias in systemic lupus erythematosus: a molecular insight.Immunometabolism (Cobham, Surrey) · 2022Review
- Should Renal Inflammation Be Targeted While Treating Hypertension?Frontiers in physiology · 2022Review
- A pregnancy hormone-cell death link promotes enhanced lupus-specific immunological effects.Frontiers in immunology · 2022Article
- Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease.Nature communications · 2021Article
- Mechanisms of hypertension in autoimmune rheumatic diseases.British journal of pharmacology · 2019Review
- Primary antiphospholipid syndrome during aromatase inhibitors therapy: A case report and review of the literature.Medicine · 2019Review
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- Intestinal macrophages in mucosal immunity and their role in systemic lupus erythematosus disease.Lupus · 2018Review
- Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study.The Journal of international medical research · 2018Article
- Tamoxifen induces apoptotic neutrophil efferocytosis in horses.Veterinary research communications · 2018Article
- Agonistic activity of tamoxifen, a selective estrogen-receptor modulator (SERM), on arthritic ovariectomized mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function.Frontiers in immunology · 2017Review
- Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review.Journal of advanced research · 2016Review
- Aromatase inhibitors and anti-synthetase syndrome.International journal of immunopathology and pharmacology · 2016Article
- NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease.Journal of biomedical semantics · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex hormones have been shown to influence the immune system and to modify the course of autoimmune disorders.
objectiveTo examine the effects of the oestrogen antagonist tamoxifen on the course of systemic lupus erythematosus (SLE) in (NZBxNZW)F1 mice.
methodsGroups of 8 week old (NZBxNZW)F1 female mice were treated with tamoxifen (800 micro g/mouse; twice a week) or with double distilled water for four months. Mice were evaluated monthly for the presence of autoantibodies directed against DNA and nuclear extract (NE) by enzyme linked immunosorbent assay (ELISA). White blood cells and thrombocytes were quantified by a cell counter and proteinuria by combistix kit. At 6 months of age, all mice that did not die spontaneously were killed and evaluated for the presence of glomerular immune deposits by indirect immunofluorescence assay. IgG isotypes of autoantibodies in the mouse sera and glomeruli were determined by gamma chain specific antibodies.
resultsTamoxifen treatment significantly reduced autoantibody production directed against either NE or DNA. The latter reduction was mainly in autoantibodies of the IgG3 isotype. Furthermore, tamoxifen had significant beneficial effects on the course of SLE in (NZBxNZW)F1 mice. At 6 months of age, 40% of the untreated mice died spontaneously, whereas all the tamoxifen treated mice were still alive. All untreated mice showed severe thrombocytopenia and persistent proteinuria, with diffuse glomerular immune deposits of IgG2a and IgG3 isotypes in their kidneys. In contrast, the tamoxifen treated mice had a normal number of thrombocytes and only minimal proteinuria. Moreover, glomerular immune deposits were detected in <40% of the tamoxifen treated mice. The latter were mainly of the IgG2a but not of the IgG3 isotype.
conclusionThe results clearly show the remarkable therapeutic effects of tamoxifen on SLE of (NZBxNZW)F1 female mice and suggest that these beneficial effects are related to the specific reduction of IgG3 autoantibodies.
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